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Ian Bosdet
Works at BC Cancer Agency
Attended University of British Columbia
Lived in Vancouver, B.C.
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Ian Bosdet

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Rajini Rao originally shared:
 
Daffodils and Dementia

✿ It's spring time in Maryland, and in the words of the poet Wordsworth, my heart dances with the daffodils. Through the long winter, I conjured up memories of these cheerful blooms in my mind:

For oft, when on my couch I lie
In vacant or in pensive mood,
They flash upon that inward eye
Which is the bliss of solitude;
And then my heart with pleasure fills,
And dances with the daffodils.

✿ But an estimated 44 million people world wide who suffer from Alzheimer's disease are robbed of their memories by a progressive dementia. As the 6th leading cause of death in the U.S., Alzheimer's cannot be cured or prevented. One of the handful of drugs available to improve memory loss in patients is galantamine, which is extracted from the leaves and bulbs of daffodils (Narcissus) and snowdrops (Galanthus). These extracts have been in use since ancient times. In Homer's Greek epic, Odysseus is said to have used snowdrops to clear his mind bewitched by Circe. In the 1950s, a pharmacologist observed inhabitants of a remote Bulgarian village rubbing the extracts on their forehead and shortly after, the drug was approved for medical use. Galantamine increases the action of the neurotransmitter acetylcholine in some parts of the brain, both by making the receptor more sensitive to its action and by slowing down its removal. The drug has other interesting properties: it is said to promote lucid dreaming, improve sleep quality, memory loss in brain damage, and some autistic symptoms (http://en.wikipedia.org/wiki/Galantamine).  

✿ No drug has yet stopped the inexorable progress of Alzheimer's. Early intervention is key to effective treatment: in my lab, for example, we are studying endosomal pathology which is the earliest sign of problems at the cellular level (http://goo.gl/DtVUFT). Yet lack of funding stifles productive research. As Newt Gingrich points out in his recent Op-Ed for New York Times, we spend only 0.8% of the estimated 154 billion dollars of annual medical costs related to Alzheimer's disease on research to cure or prevent it

News Story: Newt Gingrich: Double the NIH Budget. April 22, 2015 http://goo.gl/Fq4PAS 

Daffodil GIF: http://headlikeanorange.tumblr.com/

#ScienceSunday  
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Ian Bosdet

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"Scientists now agree—overwhelmingly—that the remedies don't work. But each year, billions of dollars worth of homeopathic products are sold in the U.S."
Remedies debunked by science make up a multibillion dollar market in the U.S.
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+Debo Capulet, they are marketed as drugs are - presented as solutions to problems. That falls under the FDA umbrella. Regarding homeopathy doing no harm, do you have a source for that? Here are (just a few of) my sources:

http://jme.bmj.com/content/36/3/130.full

http://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(05)00218-X

http://onlinelibrary.wiley.com/doi/10.1111/ijcp.12026/full

https://sciencebasedpharmacy.wordpress.com/2013/11/23/use-of-homeopathy-kills-child/

https://nccih.nih.gov/health/homeopathy
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These are so sad.

#iwishmyteacherknew I don't have a friend to play with me
Teachers around the world are using the hashtag #iwishmyteacherknew to share their students' heartfelt notes.
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Are you worried that sometimes you're too anxious?  
If you worry a lot, fear not—your anxiety just might be a sign of high intelligence. The idea has been around for a while: The adage that ignorance is bliss suggests the reverse, that knowledge involves anguish. Now it’s starting to get some scientific validation. In a recent study, for...
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I know someone... *cough..*...*cough..*
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Seven Actionable Strategies for Advancing Women in Science, Engineering, and Medicine

From the March issue of Cell Stem Cell, a report on the inaugural meeting of NYSCF’s Initiative on Women in Science and Engineering (IWISE).  

"It is the IWISE Working Group’s hope that eventually we will stop talking about women in science and start talking about equality in science, so that in time, excellence, not gender or any other measure of diversity, is the only standard that must be considered."

Here are their seven proposed strategies:

1. Implement Flexible Family Care Spending
2. Provide “Extra Hands” Award
3. Recruit Gender-Balanced External Review Committees and Speaker Selection Committees
4. Incorporate Implicit Bias Statements
5. Focus on Education as a Tool
6. Create an Institutional Report Card for Gender Equality (below)
7. Partner to Expand upon Existing Searchable Databases of Women in Science, Medicine, and Engineering
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How about ratifying the Equal Rights Amendment, for starters?
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Ian Bosdet

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This analysis looks at the validity of whole genome sequencing in a clinical setting. As this technique becomes more affordable and practical, how can we use it in this setting?

#genomesequencing   #genome  
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Ian Bosdet

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"Most reclassified #VUS (#ACMG 3 variants) are downgraded to benign"  
Anyone know of reference/data to support/refute this statement?
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"Seclusion makes gluten healthier." Totally true. Go ahead and eat that muffin if nobody is watching!

Happy Birthday +diana chard :)
Feeling alone and left out? Here's how to become gluten intolerant just like your friends....
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Haha. Thanks Ian :)
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Dr. Oz is guilty of either outrageous conflicts of interest or flawed judgements about what constitutes appropriate medical treatments, or both. Whatever the nature of his pathology, members of the public are being misled and endangered, which makes Dr. Oz's presence on the faculty of a prestigious medical institution unacceptable.
Dr. Oz is full of shit. He peddles garbage advice on his garbage TV show. And that's not just my opinion. It's science! Science which tells us that Dr. Oz gives advice that's baseless or wrong about half the time. But now his peers in the medical community are speaking out.
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Wow ... I've basically come to this conclusion without ever having watched the show; many of my extended family and some friends & acquaintances would quite pseudo-science quackery from this guy, and I often had to steer them in a better direction.  This isn't to say I knew absolutely better, just that my BS-meter would go off the chart LOL!
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Ian Bosdet

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“I knew I was right! All the research I did online paid off. No need for expensive invasive surgery with time honored treatments.”
Consider healing femur fractures with herbs and essential oils next time
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Hello
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Ian Bosdet

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Hi again.  2014 was a bit of a year for me.  We all have them every now and then, and I guess my turn came up.  One of the consequences of this is that I was largely absent from G+ for most of the year.  I continued to run across little tidbits that I thought would make great posts, but I never really found the time or energy to put many together.   But I think I’ve finally recovered enough to dive back in.  A quick browse through my stream today reminds me of what I’ve been missing and makes me wish I could rewind it for a year and catch up.
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right on
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It is a rough road that leads to the heights of greatness.
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Will pass to children and grandchildren. 
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Have him in circles
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Geoffrey Ackerman's profile photo
cuneyd Uneri's profile photo
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Education
  • University of British Columbia
    PhD, Genetics
Basic Information
Gender
Male
Relationship
Married
Story
Tagline
Molecular Geneticist
Introduction
I'm a Molecular Geneticist specializing in cancer genetics.  My primary area of interest is applications of next-generation sequencing to clinical diagnostics.  I work mostly with non-small cell lung cancers and hereditary breast and ovarian cancer but our lab does a little bit (or a lot) of everything.
Bragging rights
I'm wild-type at many loci
Work
Occupation
Molecular Geneticist
Employment
  • BC Cancer Agency
    Clinical Molecular Geneticist, present
  • University of British Columbia
    Clinical Assistant Professor, present
  • Children's and Women's Health Centre of BC
    Fellow, 2012 - 2014
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Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Previously
Vancouver, B.C.