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George Goodman
Works at Aptus Leadership Consulting
Attended University of California, San Diego
Lives in Portland, Oregon


George Goodman

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Bacterial Resistance Mechanism Exposed: New Antibiotics May Follow
A research team from the Florida campus of Scripps Research Institute has identified a novel mechanism of drug resistance. The researchers say this discovery has the potential for a major impact on the development of two high potency antibiotic medicine candidates.

“Now, because we know the resistance mechanism, we can design elements to minimize the emergence of resistance as these promising new drug candidates are developed,” said Ben Shen, Ph.D., a TSRI professor who led the study (“Mechanisms of Self-Resistance in the Platensimycin- and Platencin-Producing Streptomyces platensis MA7327 and MA7339 Strains”). The study was published online in Chemistry & Biology.
The research focuses on Streptomyces plantensis, a bacterium that protects itself from other bacteria by secreting antibacterial substances. Streptomyces plantensis is part of a large family of antibiotic-producing bacteria. This family of bacteria accounts for more than two thirds of naturally occurring clinically useful antibiotics.
The antibiotics secreted by S. Plantensis, called platensimycin (PTM) and placencin (PTN) work by interfering with the synthesis of fatty acid, which is essential for production of cell walls.
The question remained: why did these compounds kill other bacteria but not S. plantensis? Using genetic and bioinformatic techniques, the researchers identified two complementary mechanisms in the bacteria that give resistance to platensimycin and platencin. To explain, the study discovered a pair of genes in S. plantensis that exploit a pathway to simplify fatty acid synthesis while also lessening the sensitivity to these particular antibiotics.
“Knowing how these bacteria protect themselves, what the mechanisms of self-resistance of the bacteria are, is important because they could transfer that resistance to other bacteria,” said Tingting Huang, Ph.D.
“We now identify two mechanisms for PTM and PTN resistance in the S. platensis producers—the PtmP3 or PtnP3 gene within the PTM-PTN or PTN biosynthetic cluster and the FabF gene within the fatty acid synthase locus,” wrote the investigators of this study. “PtmP3/PtnP3 and FabF confer PTM and PTN resistance by target replacement and target modification, respectively. PtmP3/PtnP3 also represents an unprecedented mechanism for fatty acid biosynthesis in which FabH and FabF are functionally replaced by a single condensing enzyme. These findings challenge the current paradigm for fatty acid biosynthesis and should be considered in future development of effective therapeutics targeting fatty acid synthase.”
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Image: Depiction of bacteria, found on google images.
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George Goodman

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The Dash wireless smart in ear headphones have 4GB of internal storage, Bluetooth connectivity, heart rate monitor, blood oxygen saturation reader, thermometer, 3 hour battery life, ear bone microphone, apps and adjustable audio transparency - oh and you can swim in them too!
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This posting is two things: Work and a Good Cause.

I'm the CTO at where we provide a social competition giving platform non-profits use to raise funds. That's the Work part.

I'm also participating in the "Bowl for Adventure VIEAthon™" which benefits the Adventure Therapy programs of Oregon Active ( That's the (very) Good Cause part.

So, please visit the link below and choose to sponsor yours truly in my attempt to remember which fingers go in which holes in a bowling ball while raising money for this great program!

ps. you can participate -- go bowling and get sponsors -- too. See the special thing about a VIEAthon™ is that people participating can play anytime between the start and end dates and wherever they want (a bowling center near you -- you don't have to be in Oregon).
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George Goodman

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Papaver 'Danebrog'
by anniesannuals
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I have an old (late 2010) Macbook Air and would like to install ChromiumOS on it.  Really install it (to the SSD), not just boot from USB.  It appears I'd have been set if I'd tried it two-three years ago when Hexxeh's build was available, but all links thereto lead to nothing beyond the front page of his updated blog.

Does anyone have helpful suggestions that would lead to me having ChromiumOS running on my Macbook Air?
George Goodman's profile photoSimon Rodgers's profile photo
Thanks, Simon.  I'm going to give it a try.
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Great resources for designers and those who play designers on tv.  Or elsewhere, for that matter.
graphic, web, design, resources, deals, bundle, promotion, discount
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George Goodman lives in Portland, Oregon with his wife and near their two adult sons. George is a management leader in technology R&D.
George Goodman is:
Husband of Marsha, Father of Joel and Alden
Tech industry leader of non-profit and for-profit enterprises
Located in Portland, Oregon USA
  • University of California, San Diego
    Ph.D. Cognitive Psychology, 1976 - 1980
  • University of Florida
    B.S. Psychology, 1972 - 1976
  • Northeast High School
    1969 - 1972
  • Meadowlawn Junior High School
    1966 - 1969
  • Norwood Elementary School
    1960 - 1966
Basic Information
  • Aptus Leadership Consulting
    Founder and Consultant, 2010 - present
  • Vie Sports
    CTO & VP of Technology, 2013 - 2014
  • Climate Savers Computing Initiative
    Executive Director, 2010 - 2012
  • Intel Corporation
    Sr. R&D Director, 1991 - 2010
  • Sequent
    Engineering Manager, 1989 - 1991
  • BiiN
    Engineering Manager, 1987 - 1989
  • PARC
    Member of the Research Staff, 1985 - 1987
  • Intel Corporation
    Technical Lead, 1983 - 1985
  • Bell Labs
    Member of Technical Staff, 1980 - 1983
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Portland, Oregon
St. Petersburg, Florida - Gainesville, Florida - San Diego, California - Highland Park, New Jersey - Portland, Oregon
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