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George Goodman
Works at Aptus Leadership Consulting
Attended University of California, San Diego
Lives in Portland, Oregon
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George Goodman

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Bacterial Resistance Mechanism Exposed: New Antibiotics May Follow
 
A research team from the Florida campus of Scripps Research Institute has identified a novel mechanism of drug resistance. The researchers say this discovery has the potential for a major impact on the development of two high potency antibiotic medicine candidates.

“Now, because we know the resistance mechanism, we can design elements to minimize the emergence of resistance as these promising new drug candidates are developed,” said Ben Shen, Ph.D., a TSRI professor who led the study (“Mechanisms of Self-Resistance in the Platensimycin- and Platencin-Producing Streptomyces platensis MA7327 and MA7339 Strains”). The study was published online in Chemistry & Biology.
 
The research focuses on Streptomyces plantensis, a bacterium that protects itself from other bacteria by secreting antibacterial substances. Streptomyces plantensis is part of a large family of antibiotic-producing bacteria. This family of bacteria accounts for more than two thirds of naturally occurring clinically useful antibiotics.
 
The antibiotics secreted by S. Plantensis, called platensimycin (PTM) and placencin (PTN) work by interfering with the synthesis of fatty acid, which is essential for production of cell walls.
 
The question remained: why did these compounds kill other bacteria but not S. plantensis? Using genetic and bioinformatic techniques, the researchers identified two complementary mechanisms in the bacteria that give resistance to platensimycin and platencin. To explain, the study discovered a pair of genes in S. plantensis that exploit a pathway to simplify fatty acid synthesis while also lessening the sensitivity to these particular antibiotics.
 
“Knowing how these bacteria protect themselves, what the mechanisms of self-resistance of the bacteria are, is important because they could transfer that resistance to other bacteria,” said Tingting Huang, Ph.D.
 
“We now identify two mechanisms for PTM and PTN resistance in the S. platensis producers—the PtmP3 or PtnP3 gene within the PTM-PTN or PTN biosynthetic cluster and the FabF gene within the fatty acid synthase locus,” wrote the investigators of this study. “PtmP3/PtnP3 and FabF confer PTM and PTN resistance by target replacement and target modification, respectively. PtmP3/PtnP3 also represents an unprecedented mechanism for fatty acid biosynthesis in which FabH and FabF are functionally replaced by a single condensing enzyme. These findings challenge the current paradigm for fatty acid biosynthesis and should be considered in future development of effective therapeutics targeting fatty acid synthase.”
 
Source article: http://goo.gl/SxaymW
Image: Depiction of bacteria, found on google images.
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George Goodman

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The Dash wireless smart in ear headphones have 4GB of internal storage, Bluetooth connectivity, heart rate monitor, blood oxygen saturation reader, thermometer, 3 hour battery life, ear bone microphone, apps and adjustable audio transparency - oh and you can swim in them too!
http://homeli.co.uk/dash-wireless-smart-in-ear-headphones-by-bragi-on-kickstarter/
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George Goodman

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This posting is two things: Work and a Good Cause.

I'm the CTO at VIESports.com where we provide a social competition giving platform non-profits use to raise funds. That's the Work part.

I'm also participating in the "Bowl for Adventure VIEAthon™" which benefits the Adventure Therapy programs of Oregon Active (oregonactive.org). That's the (very) Good Cause part.

So, please visit the link below and choose to sponsor yours truly in my attempt to remember which fingers go in which holes in a bowling ball while raising money for this great program!

ps. you can participate -- go bowling and get sponsors -- too. See the special thing about a VIEAthon™ is that people participating can play anytime between the start and end dates and wherever they want (a bowling center near you -- you don't have to be in Oregon).

https://viesports.com/competitions/556-Bowling-VIEAthon-to-benefit-Oregon-Active/sponsor/73-George-Goodman
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George Goodman

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George Goodman

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Papaver 'Danebrog'
by anniesannuals
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I have an old (late 2010) Macbook Air and would like to install ChromiumOS on it.  Really install it (to the SSD), not just boot from USB.  It appears I'd have been set if I'd tried it two-three years ago when Hexxeh's build was available, but all links thereto lead to nothing beyond the front page of his updated blog.

Does anyone have helpful suggestions that would lead to me having ChromiumOS running on my Macbook Air?
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George Goodman's profile photoSimon Rodgers's profile photo
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Thanks, Simon.  I'm going to give it a try.
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Great resources for designers and those who play designers on tv.  Or elsewhere, for that matter.
graphic, web, design, resources, deals, bundle, promotion, discount
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Story
Tagline
George Goodman lives in Portland, Oregon with his wife and near their two adult sons. George is a management leader in technology R&D.
Introduction
George Goodman is:
Husband of Marsha, Father of Joel and Alden
Tech industry leader of non-profit and for-profit enterprises
Photographer
Located in Portland, Oregon USA
Education
  • University of California, San Diego
    Ph.D. Cognitive Psychology, 1976 - 1980
  • University of Florida
    B.S. Psychology, 1972 - 1976
  • Northeast High School
    1969 - 1972
  • Meadowlawn Junior High School
    1966 - 1969
  • Norwood Elementary School
    1960 - 1966
Basic Information
Gender
Male
Work
Occupation
CTO
Employment
  • Aptus Leadership Consulting
    Founder and Consultant, 2010 - present
  • Vie Sports
    CTO & VP of Technology, 2013 - 2014
  • Climate Savers Computing Initiative
    Executive Director, 2010 - 2012
  • Intel Corporation
    Sr. R&D Director, 1991 - 2010
  • Sequent
    Engineering Manager, 1989 - 1991
  • BiiN
    Engineering Manager, 1987 - 1989
  • PARC
    Member of the Research Staff, 1985 - 1987
  • Intel Corporation
    Technical Lead, 1983 - 1985
  • Bell Labs
    Member of Technical Staff, 1980 - 1983
Places
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Currently
Portland, Oregon
Previously
St. Petersburg, Florida - Gainesville, Florida - San Diego, California - Highland Park, New Jersey - Portland, Oregon
Links
George Goodman's +1's are the things they like, agree with, or want to recommend.
Snapzoom Scope Mount Review and Giveaway
www.makeuseof.com

Smartphone cameras are replacing regular cameras. Unless you're a professional photographer or a real enthusiast, you're probably not walkin

MakeUseOf
plus.google.com

Cool Websites, Tools And Internet Tips

The Ultimate Black Friday Bundle: $5,013 worth of Premium Goodies for On...
www.inkydeals.com

Black Friday is early this year! We wanted to surprise you with the biggest and most awesome Black Friday Bundle you’ve ever seen, and the r

Lumiya
market.android.com

Lumiya is a Second Life and OpenSim client with 3D world view. With Lumiya, you can send and receive instant messages, teleport to your favo

Here's How to Actually Empower Customer Service Employees
feeds.harvardbusiness.org

A five-step process for putting power in the hands of those who need it most.

Automate your Dropbox
wappwolf.com

Actions. These are some of the actions available with Wappwolf Automator for Dropbox. Documents. Convert to PDF; Summarize; Translate; PDF t

iPad2 simulator /w Css3, Jquery and HTML5 |
alexw.me

This is a jquery iPad2 simulator, this is only an experiment of what can be done with javascript in ast browsers

When My Husband Lost His Memory, I Had to Win His Love Anew
goo.gl

What’s it like when the person you love most gets amnesia and can’t remember you? Joan Bolzan on how she faced the unthinkable hurdle.

Home Solar Energy Systems More Affordable - Green Hosting | Website Host...
www.greenhostit.com

Home energy use is attracting the same sort of examination as other high-energy users, such as the web hosting industry.

Modern spacecraft from 'NASA attic' reborn by Sierra Nevada
www.msnbc.msn.com

The new spaceship being built by private aerospace firm Sierra Nevada Corp. may look like a miniature space shuttle, but while the design ta

Celebrate Earth Day’s 42nd Birthday By Turning Your Power Management On ...
www.earthtechling.com

Well over 11,000 people from around the world have supported CSCI by taking the CSCI pledge to use power management and to purchase energy e

12 Deadly Grammatical Errors Startups Must Avoid
www.readwriteweb.com

Can the difference between "it's" and "its" actually affect the fortunes of a technology startup? You might be surprised. If you're workin

Brain Implant Helps Paralyzed Hand Move : Discovery News
news.discovery.com

The device could help patients who have suffered spinal cord injuries regain the use of their limbs.

Omni Group Bundle Giveaway - Cult of Mac Deals
deals.cultofmac.com

The Omni Group Giveaway - Win $580 Worth of Productivity Apps Exclusively for your Mac!

Jennifer Pahlka: Coding a better government | Video on TED.com
www.ted.com

TED Talks Can government be run like the Internet, permissionless and open? Coder and activist Jennifer Pahlka believes it can -- and that a

Single Application Mode in OS X Keeps Your Desktop Distraction Free
lifehacker.com

It's easy to get distracted when you have a bunch of different applications open. One bouncing icon and suddenly your focus is gone and you

Repurpose LifeSavers as Birthday Cake Candle Holders
lifehacker.com

If you want to add candles to a cake without making holes in the frosting or getting wax on the cake you can use regular LifeSavers as candl

Five Best Online Custom Clothing Stores
lifehacker.com

Shopping for clothes in brick and mortar stories may give you instant gratification and the chance to try them on, but why bother when you c

NORAD ready to track Santa Claus again
news.cnet.com

For decades, the defense group has let you follow the Christmas Eve travels of the jolly old elf. These days, technology is playing a bigger

Amazonian Mushroom Eats Indestructible Plastics
gizmodo.com

We use polyurethane to make just about everything—garden hoses, furniture, the entirety of my local 99-cent store. It's easy to produce, dur