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Drug Research
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International Journal of Drug Research and Technology
International Journal of Drug Research and Technology

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In November 2017, a baby was successfully born from an embryo frozen for 24 years the longest period a viable embryo has ever been stored. Baby Emma is just one example of the amazing fertility solutions science has developed in just a few short years.
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EFFECT OF A NEW SUPRAMOLECULAR HYDROGEL AGAINST CANDIDA ALBICANS BIOFILM
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In recent decades, the incidence of fungal infections has considerable increased, particularly in immune compromised patients. Generally, opportunistic pathogens as Candida species are the main cause of invasive fungal infections, and are often associated with high morbidity and mortality. Candida albicans is a major fungal pathogen of humans, which present several virulence factors, especially the ability to form biofilm. The azoles are the mainly antifungal drugs used for the treatment of C. albicans infections. However, due to the presence of extracellular matrix, the C. albicans biofilm has significantly antifungal resistance, decreasing the efficacy of these conventional therapies. For these reasons, effective alternatives are required and increase the permeabilization of biofilm in order to antimicrobials reach deeper of this biofilm. So, in this study supramolecular polymer hydrogel was used as an alternative to increase the effectiveness of azoles. As results, the incubation (24 h) of mature C. albicans biofilms with the polymer (4%) associated with fluconazole (65 μg.mL-1) promoted ~ 70% inactivation of this fungus, while only the antifungal at same conditions inhibited ~ 40% of C. albicans. The control group (polymer 4%) it wasn’t capable to reduced fungi viability.
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Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. •    Provides needed background to…
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Explainer: How CRISPR works
Explainer: How CRISPR works
sciencenewsforstudents.org
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Cancer: Reactive oxygens make cancer more invasive
Therapeutic targeting of reactive oxygen species could help prevent the cellular transition that makes cancers more aggressive. In a review article, Canhua Huang from Sichuan University, Chengdu, China, and colleagues discuss the emerging body of evidence linking reactive oxygens — free radicals, ions or molecules containing oxygen that are generated as by-products of metabolism — to the epithelialߝmesenchymal transition (EMT) that cancer cells undergo when they gain migratory and invasive properties, changes that often lead to cancer recurrence, drug resistance, metastasis and ultimately patient death. These reactive oxygens are produced in abundance by various tumors, which have elevated metabolic rates. They fuel the EMT by remodeling the cell’s cytoskeleton and extracellular matrix, loosening adhesion between cells and enabling cell mobility. Ridding them from cancer cells could forestall this cellular transformation and curtail the spread of tumors.
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A Cancer “Atlas” to Predict How Patients Will Fare.

A systems-level approach enables analysis of the protein-coding genes of 17 different cancer types from ~8000 patients. Results are available in an interactive open-access database.

http://science.sciencemag.org/content/357/6352/eaan2507
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Ferrofluid and Magnets

Ferrofluid is a liquid that becomes strongly magnetized in the presence of a magnetic field. It is typically composed of ferromagnetic (iron) particles suspended in oil. When exposed to a magnet, the particles align with the surrounding magnetic field. The complex orientation of the ferrofluid reveals the magnetic field around the two magnets.

Source: https://youtu.be/U8SxLrh8WZQ

#ScienceGIF #Science #GIF #Ferrofluid #Magnet #Magnetic #Fluid #Iron #Particles #Align #Field #Metal #Magnetism
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