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Dominick Burton
Works at Aston University
Attended Queen Mary, University of London
Lives in Birmingham, United Kingdom
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Dominick Burton

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Abstract Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue damage. Induction of cellular senescence commonly coincides with an immunogenic phenotype that promotes self-elimination by com...
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Dominick Burton

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Abstract Mammalian cells mostly rely on extracellular molecules to transfer signals to other cells. However, in stress conditions, more robust mechanisms might be necessary to facilitate cell–cell communications. Cellular se...
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Dominick Burton

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For many researchers, irreversible cell cycle arrest is the canonical trait of senescent cells.   Such growth arrest can be induced experimentally by the up-regulation or over-expression of cyclin dependent kinase inhibitors ...
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Dominick Burton

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TGF尾-induced senescence: A growing body of evidence suggests that the members of the transforming growth factor beta (TGF- 尾) family can induce a senescence-like state. Experimentally, senescence has been predominantly, but n...
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Dominick Burton

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Senescent cells are frequently referred to as ‘apoptosis resistant’.  This apparent resistance to an apoptotic stimulus in vitro was originally reported by Wang (1995) who observed that late passage (58 population doubling) W...
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Dominick Burton

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ICSA2016 Cellular Senescence: From Molecular Mechanisms to Therapeutic Opportunities July 3-6, 2016 The David Lopatie Conference Centre Weizmann Institute of Science, Rehovot, Israel WEBSITE: http://www.weizmann.ac...
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Dominick Burton

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Senescent cells are often associated with changes in gene expression that appear to occur independent of the regulated gene expression linked to aspects of the senescent phenotype such as cell cycle arrest, the secretory resp...
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Metabolic stress, defined here as a combination of aerobic glycolysis and mitochondria dysfunction can potentially trigger a senescent state.  All organisms that use aerobic glycolysis form reactive acyclic α-oxoaldehydes (e...
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In addition to secreting soluble factors for the attraction of immune cells, senescent cells can also become immunogenic through the up-regulation of ligands that can specifically be recognized by immune cells.  While researc...
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Occupation
Research Fellow
Employment
  • Aston University
    Research Fellow, 2015 - present
    Research interests: Immunosenescence and senescence immunosurveillance. My current research interests are focused on understanding how senescent cells and immune cells interact with each other to facilitate immune clearance of senescent cells. In particular, I am interested in determining whether immunosenescence contributes to the accumulation of senescent cells in aged and diseased tissues by failing to remove them.
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Currently
Birmingham, United Kingdom
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Introduction
My research is focused on understanding the role of cellular senescence in physiological and pathological conditions.
Education
  • Queen Mary, University of London
    BSc Genetics (Hons), 1999 - 2002
  • Swansea University
    MSc Molecular Biology, 2002 - 2003
  • University of Brighton
    Cellular Senescence (PhD), 2003
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Male