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Derya Unutmaz
Works at The Jackson Laboratory for Genomic Medicine
Attended New York University School of Medicine
Lives in Farmington, CT
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Derya Unutmaz

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 Biochemists Solve the Structure of Cell's DNA Gatekeeper
Caltech scientists have produced the most detailed map yet of the massive protein machine that controls access to the DNA-containing heart of the cell.
In a new study, a team led by André Hoelz, an assistant professor of biochemistry, reports the successful mapping of the structure of the symmetric core of the nuclear pore complex (NPC), a cellular gatekeeper that determines what molecules can enter and exit the nucleus, where a cell's genetic information is stored.
The study appears in the April 15, 2016 issue of the journal Science, featured on the cover.
The findings are the culmination of more than a decade of work by Hoelz's research group and could lead to new classes of medicine against viruses that subvert the NPC in order to hijack infected cells and that could treat various diseases associated with NPC dysfunction.
The detailed map is the first to determine the structure of a massive protein machine with near-atomic resolution.
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Very well explained, must watch. An international team working at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) has captured the first high-resolution 3-D images from individual double-helix DNA segments attached at either end to gold nanoparticles. The images detail the flexible structure of the DNA segments, which appear as nanoscale jump ropes.
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Liam completes an iPhone disassembly process every 11 seconds, with dozens running through the system at all times. About 350 units are turned around each hour, equivalent to 1.2 million iPhones each year. About 350 units are turned around each hour, equivalent to 1.2 million iPhones each year. Apple wouldn't say when Liam started its work, but emphasized the project is still in the research and development stages.

Via @Mashable
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Liam means business.
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A controversial genetic technology able to wipe out the mosquito carrying the Zika virus will be available within months, scientists say.

The technology, called a “gene drive,” was demonstrated only last year in yeast cells, fruit flies, and a species of mosquito that transmits malaria. It uses the gene-snipping technology CRISPR to force a genetic change to spread through a population as it reproduces.

Three U.S. labs that handle mosquitoes, two in California and one in Virginia, say they are already working toward a gene drive for Aedes aegypti, the type of mosquito blamed for spreading Zika. If deployed, the technology could theoretically drive the species to extinction.
Fear of the Zika virus could generate support for gene drives, a radical technology able to make species go extinct.
Tullio DeSantis's profile photoHugh Tauerner's profile photoLIANMIX's profile photoBrian Fitzgerald's profile photo
If gene manipulation is so marvelous, why not target zika and malaria and dengue fever directly instead of shooting the messenger?
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In what may be a timely move, the FDA has issued clearance to RevMedX to introduce its XStat Rapid Hemostasis System for treating gunshot wounds in the civilian population. Last year the device received FDA clearance to be used on the battlefield, but now ambulances in the U.S. will have the option of carrying XStats as well.

The device contains a bunch of tablet-sized sponges that are injected, similar to using a typical syringe, deep into the wound. The tablets absorb blood and rapidly expand to fill the cavity that they find themselves in. The patient is then transported to a trauma ward where the sponges are removed and treatment can continue.
In what may be a timely move, the FDA has issued clearance to RevMedX to introduce its XStat Rapid Hemostasis System for treating gunshot wounds in the civ
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Sounds like a good thing. Now to get the doctors trained up before it hit the streets.
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It’s one of the big mysteries of cell biology. Why do mitochondria—the oval-shaped structures that power our cells—have their own DNA, and why have they kept it when the cell itself has plenty of its own genetic material? A new study may have found an answer.

Scientists think that mitochondria were once independent single-celled organisms until, more than a billion years ago, they were swallowed by larger cells. Instead of being digested, they settled down and developed a mutually beneficial relationship developed with their hosts that eventually enabled the rise of more complex life, like today’s plants and animals.
Study suggests that mitochondrial DNA may provide local control
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It's a beautiful example of symbiosis.
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Scientists say that a diverse gut microbiome is a healthy one, and it turns out that your lifestyle plays a huge role in shaping that. In a new study out of the University of Groningen in the Netherlands, researchers examined specific foods and beverages that either contributed to or impaired microbiota diversity, and found that coffee, wine and tea all helped improve people’s gut bacteria.
A new study out of the Netherlands found 60 dietary factors that can influence gut bacteria diversity.
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Everything you thought you knew about DNA's shape is wrong.

In recent years, scientists have made tremendous progress in reading the sequence of our DNA. But the three-dimensional shape of DNA remains mostly mysterious. In fact, it’s only recently that scientists have even begun to get a glimpse at how our DNA is folded. Today, scientists focus on the ways that gene mutations cause diseases like cancer. But totally normal genes can still malfunction if they get folded in the wrong way. It’s possible that ongoing research may eventually reveal a hidden world of “folding diseases.”
The reality is far messier than an abstract spiral staircase. Scientists are learning fascinating new things about how DNA is really shaped.
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"The Bullshit Asymmetry Principle" formulated by Alberto Brandolini, an Italian programmer, states that:

"The amount of energy needed to refute bullshit is an order of magnitude bigger than to produce it."
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What keeps anyone from resorting to employing rhetorical bullshit as an efficient response?
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Lasers Can Stimulate The Natural Healing Of Deeper Skin Wounds.

The “nano-suturing” technique involves the use of a medical dye, called rose bengal, that links up the skin’s collagen structural proteins. When collagen is lacking an electron, it will bond with other nearby collagen molecules. Blasting the rose bengal dye with a laser beam causes it to steal an electron from the collagen, leaving it with an odd number of electrons. In order to resolve the electron’s unpaired state, the collagen will fuse with its neighbors, hence creating a natural seal. Unlike more intrusive means of sealing wounds (like stitches and staples), this method won’t cause any inflammation or mild trauma to the skin.

In the study, the researcher tested their technique on a 10-millimeter-deep (0.39-inch-deep) cut on a deceased pig’s skin. Within 15 minutes, the wound was bonded.
Study: doi:10.1038/ncomms10374
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It's an oft-repeated idea that blind people can compensate for their lack of sight with enhanced hearing or other abilities. The musical talents of Stevie Wonder and Ray Charles, both blinded at an early age, are cited as examples of blindness conferring an advantage in other areas. Then there's the superhero Daredevil, who is blind but uses his heightened remaining senses to fight crime.

It is commonly assumed that the improvement in the remaining senses is a result of learned behavior; in the absence of vision, blind people pay attention to auditory cues and learn how to use them more efficiently. But there is mounting evidence that people missing one sense don't just learn to use the others better. The brain adapts to the loss by giving itself a makeover. If one sense is lost, the areas of the brain normally devoted to handling that sensory information do not go unused — they get rewired and put to work processing other senses.
The brain rewires itself to boost the remaining senses
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I have long suspected that my enhanced programming skill resulted from my poor sight. Maybe, I used the GPU who knows? At any rate, plasticity is the obvious answer, good to see some evidence for it!
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Humans, like all social animals, have a fundamental need for contact with others. This deeply ingrained instinct helps us to survive; it’s much easier to find food, shelter, and other necessities with a group than alone. Deprived of human contact, most people become lonely and emotionally distressed.

In a study appearing in the Feb. 11 issue of Cell, MIT neuroscientists have identified a brain region that represents these feelings of loneliness. This cluster of cells, located near the back of the brain in an area called the dorsal raphe nucleus (DRN), is necessary for generating the increased sociability that normally occurs after a period of social isolation, the researchers found in a study of mice.
Scientists identify cells that represent feelings of isolation.
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I so get this and yet other pick on all they find in someone and forget the real need. Just enjoy if a good one is near

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Scientist, Professor of Microbiology, Pathology and Medicine.
  • The Jackson Laboratory for Genomic Medicine
    Professor, 2015 - present
  • NYU School of Medicine
    Professor of Microbiology, Medicine and Pathology, 2013 - present
  • NYU School of Medicine
    Associate professor of Microbiology, Medicine and Pathology, 2006 - 2013
  • Vanderbilt University School of Medicine
    Associate Professor of Microbiology and Immunology, 1999 - 2006
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Farmington, CT
New York, NY - Nashville, TN - Siena, Italy - Basel, Switzerland - London, England - Istanbul, Turkey
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I am a biomedical scientist interested in human immunology and regenerative medicine. My research focus is to understand the basic mechanisms of human immune response and  regulation. 

Our scientific goal is to ultimately fine tune the immune system. On the one hand, we aim to find better ways to boost the immune system against infections and to develop vaccines. On the other hand, we would like to reprogram to suppress the unwanted immunity to prevent autoimmune diseases and  inflammation, which also contributes to several cancers, diabetes, cardiovascular and neurodegenerative diseases of aging. We are also developing stem cell and genetic engineering technologies to regenerate the immune system during aging and in immune deficiencies such as HIV infection. 

I am also interested in other technological advances in biological systems, robotics, nanotechnology and computation or artificial intelligence. I am highly optimistic  that we can overcome any problem our civilization encounters through science and technology.

My blog biosingularity follows some of the advances in biology, medicine and health. 

I am inspired by many remarkable people, some of whom I was greatly fortunate to know personally. However, two people have always been on the top of this list: Richard Feynman and Steve Jobs. They are also the reflection of my passion to change the world to enrich our lives through science, rational or creative thinking, elegant and practical application of technology.  Perhaps not surprisingly, I am a relentless fan of Apple products. 

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  • New York University School of Medicine
    Immunology, 1996 - 1999
  • Marmara University School of Medicine
    Medicine, 1984 - 1990
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