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Denise Case
Works at Northwest Missouri State University
Attended Kansas State University
Lived in Minnesota
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Denise Case

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Another fascinating week in science and technology - thanks +Mark Bruce​!
 
SciTech #ScienceSunday Digest - 39/2016.
Permalink here: http://www.scitechdigest.net/2016/09/fixing-dna-damage-modular-synbio.html

Fixing DNA damage, Modular synbio pellets, Towards head transplant, Custom acoustic holograms, Advanced drone systems, Wireless emotion detection, Atomically precise molecular syntheses, Metastasis gene therapy, Wireless MEMS, Sewing robot.

1. Compensating for DNA Damage
New work by the SENS Research Foundation has successfully achieved stable allotropic expression (in the nucleus), import (into mitochondria), and assembly into functional protein complexes able to rescue the cell and metabolism from mutations in the mitochondrial copies of these genes http://nar.oxfordjournals.org/content/early/2016/09/04/nar.gkw756.full. With some additional work and tricks the group hope the demonstration will allow all 13 mitochondrial genes to be moved to the nucleus and so solve one of the seven causes of aging damage, which will be important for things like sarcopenia https://www.fightaging.org/archives/2016/09/mitochondria-in-muscle-aging-and-sarcopenia/. In related work human cells engineered to contain a copy of the Dsup gene from tardigrades suffered 50% fewer DNA mutations as a result of prolonged exposure to X-rays http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/demystifying-the-resilience-of-water-bears.html; the group hope to discover related protective genes that grant tardigrades their resilience and the possibility is open to gene therapies to reduce DNA mutation rates in humans.

2. Modular DNA Expression Pellets
You can now produce bulk freeze-dried pellets containing the key cellular components needed for translating DNA to proteins - all of the enzymes, ribosomes, tRNA, etc that you need to do this basic protein production process http://news.mit.edu/2016/to-produce-biopharmaceuticals-on-demand-just-add-water-0922. The idea is that you’d have a supply of these pellets (room temp shelf-life > 1 year) and when you needed to conduct a test or produce a protein you’d synthesise your gene or DNA of interest and add it to a pellet in some water. Such cell-free synthesis is an exciting technology, another tiny step towards atomically-precise synthesis, and something that would be immediately useful for remote or at-home applications above and beyond those demonstrated: protein vaccines, antimicrobial peptides, multi-enzyme production for metabolic pathway to create a complex organic drug molecule, antibodies for diagnostics, etc.

3. Towards Human Head Transplant
Recent previous work in mice and recent work in dogs a modified solution of polyethylene glycol has been used to at least partially restore the neural connections in animals whose spines have been almost completely severed https://www.newscientist.com/article/2106382-head-transplant-teams-new-animal-tests-fail-to-convince-critics/. In the recent dog experiment the dog apparently regained the ability to walk after about three weeks. Surgeon Sergio Canavero plans to use these result to press forward with the first ever human head transplant next year, using the technique to help reconnect the severed spine of the patient’s head with the donor body. Others demand that at the lack of detailed histology data of the supposedly repaired spinal interface damages the case for proceeding in humans.

4. Custom Acoustic Holograms
Three dimensional acoustic holograms take a big step forward with a new system that uses a single powerful ultrasound transducer onto which is placed a 3D printed block that has been precisely patterned to form an acoustic hologram; ultrasound passing through the block is forced into the desired custom waveform, to levitate objects for example http://spectrum.ieee.org/tech-talk/computing/hardware/3d-printed-plastic-blocks-generate-complex-acoustic-holograms. Such a device produces an acoustic hologram with a resolution 100 times greater than previously possible with separate transducer systems. While working in air or water it can’t produce a dynamically changing waveform to move objects, although movement along fixed paths is possible. One possible way around this is to encode multiple sound fields at different frequencies to add some dynamic options.

5. Delivery, Security, Navy, Surveillance Drones
First, a cool new long range delivery drone combines a biplane design with VTOL and fixed-wing capabilities to get the best of both worlds http://spectrum.ieee.org/automaton/robotics/drones/tu-delft-tailsitter. Second, Aptonomy is launching a large security drone to monitor protected areas and intercept tresspassers https://www.technologyreview.com/s/602412/drone-security-guard-scolds-intruders-from-the-sky/. Third, the Navy’s Blackwing drone platform is designed to be launched by submarine to provide wide-area surveillance and control of other drone and communications assets https://www.avinc.com/resources/view/press-releases/united-states-navy-demonstrates-cross-domain-communications-command-and-con. Finally, DARPA’s Aerial Dragnet system is being designed to provide persistent wide-area surveillance of areas such as cities via networked drone swarms http://www.kurzweilai.net/darpas-plan-for-total-surveillance-of-low-flying-drones-over-cities.

6. Detecting Emotions with Wireless Signals
EQ-Radio is a system that uses wireless signals and reflections to measure subtle changes in a person’s breathing and heart rhythms in order to determine their emotional state http://news.mit.edu/2016/detecting-emotions-with-wireless-signals-0920. In recent tests the system was able to correctly predict whether the person was excited, happy, angry, or sad 87% of the time. Capturing human emotional states in such a way, particularly when not visibly obvious, would have uses in a wide range of different areas including security monitoring crowded events, entertainment, health care, consumer preferences, etc. The system measures heartbeats as accurately as an ECG monitor with an error margin of 0.3%.

7. Atomically Precise Molecular Chains
The size of alternative atomically precise materials that can be synthesised keeps getting larger with this recent creation of atomically precise gold nanoparticles enshrouded with a functional molecular shell and linked via a precise molecular bridge https://www.jyu.fi/en/news/archive/2016/09/tiedote-2016-09-22-15-15-43-527149. Progressively building up such units would allow the creation of ever-larger precise crystalline materials with novel electrochemical properties given that the electron clouds of the metal cores become coupled. There are also efforts to build more sophisticated catalysts by precisely combining palladium with ruthenium in different mixed or shelled structures http://phys.org/news/2016-09-combining-elements-palladium-ruthenium-industry.html.

8. Gene Therapy Stops Cancer Metastasis
A gene therapy technique involving the delivery of microRNAs of a specific sequence into cancer cells is successful in preventing those cancer cells from undergoing metastatic spread through the body http://news.mit.edu/2016/gene-therapy-technique-prevent-cancer-metastasis-0919. These microRNAs specifically regulate and block the expression of the Palladin protein that helps drive metastasis, and was delivered in this case from microRNAs embedded in nanoparticles that were loaded into a hydrogel scaffold that was subsequently implanted into the mice. Such a tool is a viable approach to cancer treatment in combination with other cancer-killing approaches. In related gene editing news, Synthego launches a CRISPR kit for labs and DIYers to make CRISPR editing easier http://synbiobeta.com/news/synthego-announces-first-kind-crispr-kit/.

9. Wireless MEMS
A microelectromechanical device has been built that can be turned on and off with a nanowatt of power from three feet away, with the concept being to use the nanoresonator itself as the antenna for the device http://www.bu.edu/research/articles/wireless-microelectromechanical-systems/. The device achieved an efficiency of 15% and the group believes it might find application in optogenetics to provide a route for wireless power and communications to devices implanted in and interfaced to the brain. But such wireless MEMS could be used everywhere: for example a modified router might monitor wireless MEMS sensors placed on movable objects all over the house.

10. A Sewing Robot
Sewbo has launched a robot to automate garment sewing, such as the sewing that typically takes place en masse in sweatshops https://www.technologyreview.com/s/602423/a-robot-that-sews-could-take-the-sweat-out-of-sweatshops/. It doesn’t have the versatile flexibility of human sewing of course, and the key innovation is a method to temporarily hold the garment fabric in solid sheet form (it uses off-the-shelf sewing machines and robotic arms) that can be more easily picked up and guided by automated systems, but which when plunged into warm water removes the polymer to return it back to the soft flexible garment for sale and use. This gets us towards fully automated garment production.

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Cheers!
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Denise Case

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Leaked NSA hacking tool gets a lackluster review. From the article:
Stephen Checkoway, an Assistant Professor at the Department of Computer Science at the University of Illinois at Chicago, has analyzed some of the exploit code included in the recent Equation Group leak, and his verdict is "not impressed."

Over the past weekend, a person or group named The Shadow Brokers published a set of hacking tools they claim to have stolen from the Equation Group, a name given by security vendors to a cyber-espionage group believed to be linked to the US National Security Agency (NSA).

The hackers dumped a small sample of the tools so that security researchers can verify the dump's validity. The rest of the data is available in a password-protected encrypted archive.

The Shadow Brokers are currently holding an auction to sell the rest of the data to the highest bidder.

#computerscience #hacking   #nsa  #security #exploit #espionage #ethics #ShadowBrokers #code

Read more: http://news.softpedia.com/news/computer-science-professor-gives-failing-grade-to-newly-leaked-nsa-hacking-tool-507482.shtml#ixzz4I4rQYHXn

Via +CodeProject Daily Developer News
http://www.codeproject.com/script/Mailouts/View.aspx?mlid=12379&_z=11048811
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coucou salut

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Denise Case

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Have a wonderful 2-day! :)

Thanks +Amine Benaichouche
 
In the format DD/MM/YY.
There is no special meaning or superstitious interpretations for this day. This remark is just for fun.

#Mathematics #MathematicsForFun 
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works for me! love it.
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State of the Climate report. Environmental records shattered as climate change 'plays out before us'

"The world is careening towards an environment never experienced before by humans, with the temperature of the air and oceans breaking records, sea levels reaching historic highs and carbon dioxide surpassing a key milestone, a major international report has found."

"The “state of the climate” report, led by the National Oceanic and Atmospheric Administration (Noaa) with input from hundreds of scientists from 62 countries, confirmed there was a “toppling of several symbolic mileposts” in heat, sea level rise and extreme weather in 2015."

http://www.theguardian.com/environment/2016/aug/02/environment-climate-change-records-broken-international-report

#climatechange 
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We Chose to Go To The Moon. Forty-seven years ago, on July 20, 1969, a curious courageous species stepped onto the surface of a distant world. After surviving the explosive force needed to escape Earth's gravity and enduring a three-day ride through nearly empty space to enter lunar orbit, Neil Armstrong and Buzz Aldrin piloted a lander down to the surface, descended a ladder, and spent two hours working on the moon. Then, perhaps even more amazing, on July 21, they launched part of the Eagle lander back up to dock with Michael Collins in the orbiting Columbia, blasted out of lunar orbit and rode the tiny return craft back home, falling into the Pacific Ocean near Hawaii. Hundreds of thousands of mission contributors helped us cross the final frontier - and got us back safely.

"Over the next three and a half years, 10 astronauts [would follow] in their footsteps. Gene Cernan, commander of the last Apollo mission leaves the lunar surface with these words: "We leave as we came and, God willing, as we shall return, with peace, and hope for all mankind." [1]

Apollo 11 Introduction (2 min video)

https://www.youtube.com/watch?v=8il6rx-9a3c

Apollo 11 Flight Log, July 21, 1969: Launching from the Moon
with Apollo 11 Retrospective: 'One We Intend to Win' (4 min video)

http://www.space.com/26585-apollo-11-flight-log-july-21-1969.html

[1] https://www.nasa.gov/mission_pages/apollo/apollo11.html


#nasa   #apollo11   #lunarlanding   #spaceexploration   #humansareamazing  
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Mother gorilla with twins :)

#twofun #twins #nothingbetter #familytree 
Mother gorilla holding twins, by Jeff Milsteen Cute or not? Please Follow:- +Amusing Feed - Charles Filipponi - Google+
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Interactive map shows comparative country size. Nicely done.

#geography #world #interactive #data #visualization #map
 
One of our most popular posts of the past week: Your country might be bigger - or smaller - than you thought.
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Thanks for this Denise - a nice little resource
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The Sustainable Economic Development Assessment index tracks 160 countries across three elements: economic, sustainability and investment. These elements are made up of 10 dimensions, which include factors such as income equality, health, education and infrastructure.

#progress #policy #investment #economics #sustainability
 
And which countries are making the most progress?
Some of the wealthiest countries in the world are failing to convert economic growth into well-being for their citizens.
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#67P looking very dramatic. Image shot from a distance of 8km by #OSIRIS camera on board #Rosetta . Image taken on 27 July 2016.

More here: https://planetgate.mps.mpg.de/Image_of_the_Day/public/OSIRIS_IofD_2016-08-02.html

Credit: ESA/Rosetta/MPS for OSIRIS Team MPS/UPD/LAM/IAA/SSO/INTA/UPM/DASP/IDA
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Global warming: demand the truth

After announcements that 2015 was the hottest year on record and February 2016 was the hottest month, the news station CNN aired five times more fossil fuel advertising than actual climate reporting!

So, please sign this petition to CNN.  Tell them: start reporting on climate change.   And please reshare this message.

A study by the group Media Matters showed that the American Petroleum Institute is getting more coverage than actual news about global warming.  This doesn't even include the ads from individual fossil fuel companies and the Koch brothers.

Here's some actual news, in case you hadn't heard:

1) The extent of Arctic sea ice in June was the lowest in recorded history for that month of the year: 260,000 square kilometers less than ever before!   It's on track to break all records this year.

2) Recently every month from October until May has been the hottest on record worldwide.  June was the second hottest, since the El Niño is fading.

3) India recorded its hottest day ever on May 19th. The temperature in Phalodi hit 51 degrees Celsius (124 degrees Fahrenheit), and a nationwide drought has affected more than 300 million people marched on, leaving armed guards at dams, and reservoirs well below their usual levels.

4) Alaska, along with the rest of the Arctic, has experienced record-breaking heat this year.  Its average year-to-date temperature has been 5.5C above the long term average.

5) In the atmosphere, carbon dioxide has been increasing every year for decades - but this year the speed of increase is also record-breaking!   The increase for 2016 is expected to be 3.1 parts per million, up from an annual average of 2.1.

6) The Great Barrier Reef, a natural wonder and world heritage site, recently experienced its worst ever coral bleaching event.  An aerial study found that just 7% of the reef escaped bleaching. 

7) A new study in Nature argues that even despite the actions pledged in the Paris Agreement, the Earth is still on course for a temperature increase of 2.6 - 3.1C by the end of this century.  Read this:

http://www.nature.com/nature/journal/v534/n7609/full/nature18307.html

The Paris agreement is a step in the right direction, but we need to ratchet it up.  We can't afford to slack off now.  One piece of the puzzle is clear information about the crisis we're in.

----------------------------------------------

Media Matters writes:

In Week After Hottest Year Announcement, CNN Aired Less Than One Minute Of Climate-Related Coverage And 13.5 Minutes Of Oil Industry Ads.

From January 20 to January 26, CNN morning, daytime and primetime programming included only 57 seconds of coverage about climate change or the announcement that 2015 was the hottest year on record. Over that same time period, CNN aired 13.5 minutes of American Petroleum Institute ads. The climate-related segments included one on the January 21 edition of Early Start, in which anchor Christine Romans reported that 2015 was the hottest year on record and that officials say “the planet is still warming with no apparent change in the long term global warming rate.” Additionally, CNN senior legal analyst Jeffrey Toobin briefly mentioned Republican climate science denial during a discussion of Hillary Clinton’s emails on Anderson Cooper 360, and CNN host Fareed Zakaria noted that the “The World Economic Forum said this year that the greatest global risk is the failure of climate change mitigation and adaptation,” during a Fareed Zakaria GPS segment about a study finding that humans have entered a new geological epoch known as the Anthropocene.

Following Announcement That February 2016 Was Most Unusually Hot Month Ever, CNN Aired Four Minutes Of Climate-Related Coverage And 10 Minutes Of Fossil Fuel Ads.

In the one-week period beginning March 17, when NOAA released data showing that February 2016 was the most unusually hot month ever recorded, CNN aired only four minutes of coverage about climate change or the temperature record during its morning, daytime, and primetime coverage. During that same time period, CNN aired ten minutes of American Petroleum Institute ads. On March 18, CNN anchors Christine Romans and John Berman delivered nearly-identical reports on February’s “astounding” temperature record during the 4 a.m. and 5 a.m. editions of Early Start, respectively, but neither explicitly mentioned climate change or the role fossil fuel pollution and other human activities play in driving climate change. The March 20 edition of Fareed Zakaria GPS featured an interview with astronaut Piers Sellers about his climate change advocacy, followed by a brief report about International Energy Administration (IEA) data showing a decline in carbon emissions from energy production, which Zakaria described as “some good news on the climate front” and a “welcome update in the climate battle.” Finally, on the March 20 edition of New Day Sunday, anchor Christi Paul reported that major cities around the world were participating in Earth Hour, an event meant to bring awareness to climate change, by switching off their lights.

For more details see:

http://mediamatters.org/research/2016/04/25/study-cnn-viewers-see-far-more-fossil-fuel-advertising-climate-change-reporting/209985

Here's the data for the statements 1)-6):

https://www.theguardian.com/environment/2016/jun/17/seven-climate-records-set-so-far-in-2016

https://www.theguardian.com/environment/2016/jul/07/arctic-sea-ice-crashes-to-record-low-for-june

http://www.netnewsledger.com/2016/07/05/june-2016-second-hottest-june-ever/
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Denise's Collections
Story
Tagline
The secret of life is two words: not always so :)
Introduction
A Few Favorite Quotes


A ship in harbor is safe. But that is not what ships are for.
- Rear Admiral (and Computer Scientist) Grace Hopper


There should be no boundary to human endeavor.

- Stephen Hawking


My undergraduate experience convinced me that I was not smart enough to be a physicist, and that computers were quite neat.

- Dennis Ritchie

Never give up
No matter what is going on
Never give up
Develop the heart
Too much energy in your country
Is spent developing the mind
Instead of the heart
Be compassionate
Not just to your friends
But to everyone
Be compassionate
Work for peace
And I say again
Never give up
No matter what is going on around you
Never give up

- HH Dalai Lama XIV

Education
  • Kansas State University
    PhD Computer Science, 2013 - 2015
  • Kansas State University
    MSE Software Engineering, 2013
  • University of Missouri–Columbia
    BS Chemical Engineering
Basic Information
Gender
Female
Work
Occupation
“The master in the art of living makes little distinction between his work and his play, his labor and his leisure, his mind and his body, his information and his recreation, his love and his religion. He hardly knows which is which. He simply pursues his vision of excellence at whatever he does, leaving others to decide whether he is working or playing. To him he's always doing both. ” ― James A. Michener
Employment
  • Northwest Missouri State University
    Asst Professor, present
  • Johnson County Community College
    Adjunct Asst. Professor, 2013
  • Black & Veatch
    Consulting Engineer, 2015
  • Kansas State University
    Graduate Student, 2011 - 2015
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Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Previously
Minnesota - Kansas
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