Cover photo
Denise Case
Attends Kansas State University
Lived in Minnesota
20,740 followers|990,660 views


Denise Case

Shared publicly  - 
He calls it a "very sexy curve on a graph" and it will be a game changer.  Highly recommended article on the economics of energy from +Mark Bruce and +David Fuchs

When we think of the huge role our concentrated energy sources play in politics, war, and the economy, it's amazing. Adequate levels of distributed energy really will change everything.  
Cade Johnson's profile photoMatthew Turk's profile photo
I am not sure I grasp the conclusion; if the petroleum industry devalues long-term reserves, what effect will this have on their business practices? In fact, petroleum is useful for more than just energy production but the value over business cycle time horizons must decline if other forms of energy production are competing.
Add a comment...
Does the past and the future exist in the same way as the present? Some physicist's answers might be surprising. :)

+Sabine Hossenfelder on the problem of Now.

#blockuniverse # spacetime
The Problem of Now
[ Image Source ] Einstein’s greatest blunder wasn’t the cosmological constant, and neither was it his conviction that god doesn’t throw dice. No, his greatest blunder was to speak to a philosopher named Carnap about the Now, with a capital. “The problem of ...
Denise Case's profile photo
Is it "does" ... or "do"?
Add a comment...
First, make it right. Then, make it fast.  Obscuring code to make it run faster isn't always necessary or desirable, but when it matters - like creating Burrows-Wheeler transforms from billion-base pair genomes - Pearls of Functional Algorithm Design looks like it would be an interesting reference. 

Thanks +Claudia Doppioslash for sharing. :)

How to Read:

(Includes an example BWT pearl )  o_0

Front Matter:


Find in a Library:

How to Write a Functional Pearl (Slides from Richard Bird's talk):


Pearls contain:
- Instructive examples of program calculation or proof;
- Nifty presentations of old or new data structures;
- Interesting applications and programming techniques.

It includes notes on the pearlization of Simple Sudoku Solving and a reference to various Sudoku solvers in Haskell:

#nextgenerationprogramoptimization   #computerscience  
Задравин Алексей's profile photo
Add a comment...
Imagine a world without hate.   Humans are capable of such wonderful things, but there remains a side to us that too easily distances ourselves from others.  Efforts to dehumanize and marginalize some of us, reduce us all. 

Our thoughts are with the family and friends of those hurt and killed in Overland Park and with all those consumed with anger and tortured by hatred.

Imagine a World Without Hate (Official Video)
John Lennon - Imagine (official video)

Mark Bruce's profile photoKhalid Fathi's profile photoVinod Pandey's profile photo
"Efforts to dehumanize and marginalize some of us, reduce us all." well said Denise. 
Add a comment...
Happiness Science. Practical suggestions for how to quiet our inner critics and saboteurs - and activate our innate Jedi sage superpowers. Great talk by Professor +Shirzad Chamine on "Positive Intelligence" and the science of increasing happiness and performance.

The talk includes simple, actionable strategies for making a positive difference.  No equipment needed - you can start with just 10 seconds! (On your own - or with a friend.)  :) 

It's hard enough to fight enemies with outposts in our brains, harder still, when we can't see them.  The website includes a quick quiz to find out what we might be dealing with.

NY Times Bestseller:

Thanks +Derya Unutmaz for sharing! :)

#science  #happiness  #humanpotential #positiveintelligence
Stanford Professor Shirzad Chamine is author of the New York Times bestseller Positive Intelligence. His work exposes 10 well-disguised mental saboteurs and shares how to defeat them. According to Chamine, "positive intelligence" measures the percentage of time our mind serves us as opposed to sabotaging us. 
Hector Ramos's profile photoKristin Gleitsman's profile photo
Add a comment...
Might be time to update 4-digit pin codes, too. :)

The chart shows the relative frequency of various 4-digit pin codes. Sequences, 4-digit years, and 4-digit day-month combinations are obvious favorites. :)

Thanks +Boris Borcic+roger wattenhofer, and +Mark Maimone.  

#security   #datavisualization   #art
Beautiful abstract art?

Rather this is a graphical representation of the frequency of four digit PIN codes. On the x-axes we have the first two PIN digits from 00.. to 99.., on the y-axes we have the last two digits from ..00 to ..99. Popular PIN codes include the yellow diagonal, PIN codes of the form XYXY, and even more bright XXXX. The vertical yellow line are PIN codes marking a year, mostly between the years 1930-2010. The yellow blob on the lower left are US formatted calendar days from 01/01 to 12/31 (you can even see how many days each month has). Also singleton yellow dots can be explained.

Anyway, it is beautiful, in my opinion.
Bill DeWitt's profile photoDenise Case's profile photoMorgan Catlin's profile photo
Great catch  +Bill DeWitt -  8068 got the disproportionately least amount of  love:
"In my dataset the answer is  8068  with just 25 occurrences in 3.4 million (this equates to 0.000744%, far, far fewer than random distribution would predict, and five orders of magnitude behind the most popular choice)."

No idea why though...what's so bad about 8068?  

8080 is on the popular diagonal since it repeats... nothing especially good or bad about Intel's notable 8086. :)
Add a comment...
Have her in circles
20,740 people
Earth-size and habitable-zone. :) A good candidate for liquid water and rocky terrain.  We don't know yet what the composition is - but we've seen that combination before - and it's given rise to some of the most complex, beautiful, insightful, and curious parts of the known Universe. 

NASA's Kepler Mission Discovers First Earth-Size Planet In The 'Habitable Zone' of Another Star!
April 17, 2014: This artist's concept depicts Kepler-186f, the first validated Earth-size planet to orbit a distant star in the habitable zone. Using NASA's Kepler Space Telescope, astronomers have discovered the first Earth-size planet orbiting a star in the "habitable zone"—the range of distance from a star where liquid water might pool on the surface of an orbiting planet. The discovery of Kepler-186f confirms that planets the size of Earth exist in the habitable zone of stars other than our sun.

While planets have previously been found in the habitable zone, they are all at least 40 percent larger in size than Earth and understanding their makeup is challenging. Kepler-186f is more reminiscent of Earth.
"The discovery of Kepler-186f is a significant step toward finding worlds like our planet Earth," said Paul Hertz, NASA's Astrophysics Division director at the agency's headquarters in Washington. "Future NASA missions, like the Transiting Exoplanet Survey Satellite and the James Webb Space Telescope, will discover the nearest rocky exoplanets and determine their composition and atmospheric conditions, continuing humankind's quest to find truly Earth-like worlds."

Although the size of Kepler-186f is known, its mass and composition are not. Previous research, however, suggests that a planet the size of Kepler-186f is likely to be rocky.

"We know of just one planet where life exists -- Earth. When we search for life outside our solar system we focus on finding planets with characteristics that mimic that of Earth," said Elisa Quintana, research scientist at the SETI Institute at NASA's Ames Research Center in Moffett Field, Calif., and lead author of the paper published today in the journal Science. "Finding a habitable zone planet comparable to Earth in size is a major step forward."

Kepler-186f resides in the Kepler-186 system, about 500 light-years from Earth in the constellation Cygnus. The system is also home to four companion planets, which orbit a star half the size and mass of our sun. The star is classified as an M dwarf, or red dwarf, a class of stars that makes up 70 percent of the stars in the Milky Way galaxy.
"M dwarfs are the most numerous stars," said Quintana. "The first signs of other life in the galaxy may well come from planets orbiting an M dwarf."

Kepler-186f orbits its star once every 130-days and receives one-third the energy from its star that Earth gets from the sun, placing it nearer the outer edge of the habitable zone. On the surface of Kepler-186f, the brightness of its star at high noon is only as bright as our sun appears to us about an hour before sunset.

"Being in the habitable zone does not mean we know this planet is habitable. The temperature on the planet is strongly dependent on what kind of atmosphere the planet has," said Thomas Barclay, research scientist at the Bay Area Environmental Research Institute at Ames, and co-author of the paper. "Kepler-186f can be thought of as an Earth-cousin rather than an Earth-twin. It has many properties that resemble Earth."

The four companion planets, Kepler-186b, Kepler-186c, Kepler-186d, and Kepler-186e, whiz around their sun every four, seven, 13, and 22 days, respectively, making them too hot for life as we know it. These four inner planets all measure less than 1.5 times the size of Earth.
The next steps in the search for distant life include looking for true Earth-twins -- Earth-size planets orbiting within the habitable zone of a sun-like star -- and measuring the their chemical compositions. The Kepler Space Telescope, which simultaneously and continuously measured the brightness of more than 150,000 stars, is NASA's first mission capable of detecting Earth-size planets around stars like our sun.

Ames is responsible for Kepler's ground system development, mission operations, and science data analysis. NASA's Jet Propulsion Laboratory in Pasadena, Calif., managed Kepler mission development. Ball Aerospace & Technologies Corp. in Boulder, Colo., developed the Kepler flight system and supports mission operations with the Laboratory for Atmospheric and Space Physics at the University of Colorado in Boulder. The Space Telescope Science Institute in Baltimore archives, hosts and distributes Kepler science data. Kepler is NASA's 10th Discovery Mission and was funded by the agency's Science Mission Directorate.

The SETI Institute is a private, nonprofit organization dedicated to scientific research, education and public outreach.  The mission of the SETI Institute is to explore, understand and explain the origin, nature and prevalence of life in the universe.

Credit: NASA Ames/SETI Institute/JPL-Caltech

+NASA Ames Research Center 
+NASA Jet Propulsion Laboratory 

#NASA   #Exoplanet   #Space #Astronomy #Kepler186f #Earth #Habitable #Kepler #Life #Star #Universe #Cosmos
Allen Hildebrandt's profile photoMichael Rowe's profile photoJoerg Fliege's profile photoEric Jensen's profile photo
Ed S
For a long-term view, better to attach our loyalty to DNA-based life, rather than to humanity.  Having said which, computational life forms might stand a much better chance - it can readily sit out long journeys, and it can fork exact copies (if that's advantageous)
For a bit of fun, see the texts at 
Add a comment...
Brain shark.  That's Naeglaria fowleri  - "the brain eating amoeba chomping away."   And there's more.  :)

Another interesting article from +Lacerant Plainer :) 

For more weird - but fascinating - biology, see the Daily Parasite at :)


#biology #originofaspecies #dailyparasite
Literally eating people alive : No kidding. We have heard of Naeglaria fowleri, the brain eating amoeba found in water. Now there is new research that shows that the parasite Entamoeba histolytica , which was earlier thought to kill human cells by toxins, actually eats them while they are still alive.

Article Extract: It used to be thought that the parasite Entamoeba histolytica killed human cells with toxins and only ate them once they were dead--and that during its meals, it would eat cells by engulfing them whole, like other amoebas. But a new study shows that these parasites instead chomp on human cells while they are still alive, taking little bites until the cells die and then moving on.

“This process of nibbling of cells went unrecognized by everyone in this field, including me, for over a hundred years,” study co-author and infectious disease specialist William Petri of the University of Virginia in Charlottesville told Science. This habit of chewing bits of live cells in this way and moving on is remarkably strange, and basically unprecedented. "The ingestion of live cell material and the rejection of corpses illuminate a stark contrast to the established model of dead cell clearance in multicellular organisms."

Main article from +Popular Science  :

Article link from +Gizmodo :

Wikipedia link on Entamoeba histolytica :

Research link from +Nature Publishing Group :

Sciencemag link:

Pics courtesy : Luke Jerram ( main pic, Glass sculpture of an Amoeba. Pic on right top (, Naeglaria fowleri, the brain eating amoeba chomping away. Pic on right bottom : Entamoeba histolytica cyst from Wikipedia (

#amoeba #science #biology
Mark Bruce's profile photoDenise Case's profile photoDavid Ford's profile photo
Thanks, I think +Mark Bruce :)   One of the really nice things about being born where/when we were is not being nearly as likely to experience certain things first-hand. :) Sometimes science from a safe distance is fascinating enough. :) 
Add a comment...

Denise Case

Shared publicly  - 
Kind of like it when you put it like that.  :)   

Thanks +Gary Rudd :)  

When you put it like that, Wednesdays don't seem so bad after all...

#space #science #astronomy #universe #cosmos 
Peter Brunner's profile photoJustin Randall's profile photoEdwin Perello's profile photoMichael Forbes's profile photo
The way I express it is "it helps to have a sense of perspective".

Add a comment...
Mostly Microbe. Our microbes may be essential to our health - and our happiness.  For every human gene in our genome, there are 100 bacterial genes in our microbiome; in many ways we are "more microbe than human."   

5 minute video from +NPR offers a quick and engaging introduction to our invisible partners:
The Invisible Universe Of The Human Microbiome

+Lacerant Plainer's informative article on Our Microbial World:

NY Times:  Some of My Best Friends are Germs
(+Michael Pollan May 15, 2013)

Excerpt 1: Gut microbes may have a powerful influence on metabolism:

Justin Sonnenburg, a microbiologist at Stanford, suggests that we would do well to begin regarding the human body as “an elaborate vessel optimized for the growth and spread of our microbial inhabitants.” This humbling new way of thinking about the self has large implications for human and microbial health, which turn out to be inextricably linked. Disorders in our internal ecosystem — a loss of diversity, say, or a proliferation of the “wrong” kind of microbes — may predispose us to obesity and a whole range of chronic diseases, as well as some infections. “Fecal transplants,” which involve installing a healthy person’s microbiota into a sick person’s gut, have been shown to effectively treat an antibiotic-resistant intestinal pathogen named C. difficile, which kills 14,000 Americans each year. (Researchers use the word “microbiota” to refer to all the microbes in a community and “microbiome” to refer to their collective genes.) ... A similar experiment was performed recently on humans by researchers in the Netherlands: when the contents of a lean donor’s microbiota were transferred to the guts of male patients with metabolic syndrome, the researchers found striking improvements in the recipients’ sensitivity to insulin, an important marker for metabolic health. Somehow, the gut microbes were influencing the patients’ metabolisms.

Excerpt 2:  Thinking with your gut (microbes) :)

Our gut bacteria also play a role in the manufacture of substances like neurotransmitters (including serotonin); enzymes and vitamins (notably Bs and K) and other essential nutrients (including important amino acid and short-chain fatty acids); and a suite of other signaling molecules that talk to, and influence, the immune and the metabolic systems. Some of these compounds may play a role in regulating our stress levels and even temperament: when gut microbes from easygoing, adventurous mice are transplanted into the guts of anxious and timid mice, they become more adventurous. The expression “thinking with your gut” may contain a larger kernel of truth than we thought.

It's a Gut Feeling - how the gut microbota affects the state of mind:

Gut microbiome-host interactions in health and disease:
(Kinross et al. Genome Medicine 2011, 3:14)
See Figure 1 for a quick overview of some promising medical areas.

PharmacoMicrobiomics or How Bugs Modulate Drugs

Nanotechnology and Learning to Talk to Bacteria:
Nanotechnology and learning to talk to bacteria: Reginald C. Farrow at TEDxNJIT
TEDx talk by 

HMP: NIH Human Microbiome Project

Infographic:  A map of diversity in the human microbiome

+Mark Bruce's SciTech Digest this week includes an entry for nanobots that can dynamically fold DNA sequences to deliver custom cellular payloads.  

"DNA Researchers have produced a variety of DNA Origami sequences that self-assemble into different nanorobots capable of interacting with biological substrates, and each other, while inside a living animal"

Happy #ScienceSunday  - the world is more amazing than we could have imagined. :)

#sciencesunday   #stemeducation   #genomics #medicine
Denise Case's profile photoJürgen Christoffel's profile photoLacerant Plainer's profile photoMs. Frisby's profile photo
+Bob Calder I should add that to my must see list. Interesting, the story line sounds evocative :)
Add a comment...
Have her in circles
20,740 people
“The master in the art of living makes little distinction between his work and his play, his labor and his leisure, his mind and his body, his information and his recreation, his love and his religion. He hardly knows which is which. He simply pursues his vision of excellence at whatever he does, leaving others to decide whether he is working or playing. To him he's always doing both. ” ― James A. Michener
  • Consulting Engineer, present
  • Adjunct Asst. Professor, present
  • Kansas State University
    Graduate Student, present
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Minnesota - California - Kansas
The secret of life is two words: not always so :)
Favorite Quotes

"A ship in harbor is safe. But that is not what ships are for." 
- Rear Admiral (and Computer Scientist) Grace Hopper

"Do not believe in anything simply because you have heard it. Do not believe in anything simply because it is spoken and rumored by many. Do not believe in anything simply because it is found written in your religious books. Do not believe in anything merely on the authority of your teachers and elders. Do not believe in traditions because they have been handed down for many generations. But after observation and analysis, when you find that anything agrees with reason and is conducive to the good and benefit of one and all, then accept it and live up to it." 
- Siddhartha Gautama
  • Kansas State University
    PhD Candidate Computer Science, 2013 - present
  • Kansas State University
    MSE Software Engineering, 2013
  • University of Missouri–Columbia
    BS Chemical Engineering
Basic Information