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Creative Biogene
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Stable cell line, particles, cDNA, miRNA
Stable cell line, particles, cDNA, miRNA

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Transposase (Tnp) Tn5 is a member of the RNase superfamily of proteins which includes retroviral integrases. Tn5 is utilized in genome sequencing for fragmentation of the DNA, in the technique called ATAC-seq. A great advancement in library preparation was the introduction of a hyperactive variant of the Tn5 transposase that mediates the fragmentation of double-stranded DNA and ligates synthetic oligonucleotides at both ends in a 5-min reaction. Creative Biogene provides robust Tn5 transposase for accelerating your research, especially tagmentation-based sequencing library construction. https://www.creative-biogene.com/Product/Tn5-Transposase.html
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Creative Biogene offers a dedicated epigenetic screening and profiling assay services designed to be flexible and innovative in order to help you the success of your projects. The high-throughput platform allows us to screen a chemical library against particular epigenetic biochemical targets. Alternatively, our comprehensive collection of epigenetic enzymes, substrates, and off-the-shelf assays enable us analyzing of the activity of a few compounds against several targets. https://www.creative-biogene.com/Services/Drug-Discovery-Services/Epigenetic-Screening-Profiling-Services.html
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With increasing evidence of safety and efficacy in clinical trials, oncolytic viruses offer a ray of hope in fighting against cancers. Live attenuated measles virus (MeV) can be developed for oncolytic use. Creative Biogene has developed Measles Virus (MeV) Platform with the goal of promoting the research progress in cancer treatment by means of oncolytic measles viruses. https://www.creative-biogene.com/services/Measles-Virus-MeV-Service.html
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RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules. It is a valuable research tool because synthetic dsRNA introduced into cells can selectively and robustly induce suppression of specific genes of interest. shRNA is an advantageous mediator of RNAi in that it has a relatively low rate of degradation and turnover. Creative Biogene offers the generation of cell lines stably expressing shRNAs targeting a gene of interest. We will design your shRNAs and integrate them into virtually any cell line you choose. https://www.creative-biogene.com/Services/Stable-cell-line-generation/Custom-Gene-Knockdown-Cell-Lines.html
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CRISPR (Clustered Regulatory Interspaced Short Palindromic Repeats)/Cas9 systems is a newly developed yet the most popular method for genome editing. It has been widely used in current biology, functional genome screening, cell-based human hereditary disease modeling, epigenomic studies and visualization of cellular processes. Creative Biogene's scientists are experts at performing gene knockout with CRISPR/Cas9, from designing gRNA constructs to transfection and single clone generation of a wide range of cells, including difficult-to-transfect and tumor cell lines. https://www.creative-biogene.com/Services/Stable-cell-line-generation/Custom-Genome-Editing-Cell-Lines.html
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To obtain more specific biophysical and pharmacological analysis, scientists simplify ion channels by expressing it in cultured, non-neuronal cell lines. Creative Biogene has the most extensive collection of cell lines stably expressing functional ion channels, including Nav, Cav, ERG and others. These cell lines are carefully selected for optimal performance thus ensuring a high level of accuracy and precision in the assays. https://www.creative-biogene.com/Product/Ion-Channel-Stable-Cell-Lines.html
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Creative Biogene can synthesize and clone any DNA sequences, even complex, GC-rich, repeated, or long genes, into prokaryotic, eukaryotic or viral vectors. With years of experience in the gene synthesis and cloning field, Creative Biogene can provide the most professional service with fastest turnaround time to customers worldwide. https://www.creative-biogene.com/Services/Gene-Service/Gene-Synthesis-and-cloning-service.html
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CRISPR (Clustered Regulatory Interspaced Short Palindromic Repeats)/Cas9 systems is a newly developed yet the most popular method for genome editing. Besides the basic employment of gene knock-out, CRISPR/Cas9 system can be applied to selective gene activation and repression, purification of specific genomic DNA and fluorescent protein-tagging in live cells through modifications of the Cas9. Creative Biogene’s series products of CRISPR/Cas9 are mainly used for sgRNA vector constructing, sgRNA identification, screening to select the most active sgRNAs and knockout detection. https://www.creative-biogene.com/Product/Gene-Editing-Kits.html
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Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded DNA oligos that are designed to specifically bind to a target messenger RNA (mRNA) by Watson–Crick hybridization, inducing selective degradation of the mRNA or prohibiting translation of the selected mRNA into protein. The hybridization of the ASO and a target mRNA depends on design and chemistry modification, which may result in selective degradation by endogenous nucleases, or alternatively, inhibition of the processing and/or function of the mRNA by an occupancy-only mechanism. ASO technology provided an oligonucleotide-based approach to disrupting gene expression and has become effective tools in basic molecular biology, and proteomics research, often used for target screening and validation as well as for drug discovery. https://www.creative-biogene.com/services/Antisense-Oligonucleotides-Synthesis-Service.html
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