I hope it can, I really do, and I haven't ruled it out. The Alcubierre Drive, or something along those lines, is the most promising idea, but that has its own set of problems, as I've already mentioned with expanding spacetime.
Other suggested methods: wormholes seem to my limited mathematical knowledge, to defy the law of conservation of energy. I think they exist and may well be the mechanism behind entanglement, but I also have a suspicion they collapse at the macroscopic scale due to gravity... and I also suspect the same for quantum uncertainty, and if we ever manage to consolidate quantum physics with general relativity we should find out for sure.
I'm very confident that black holes will be very useful for research on the early universe, especially the Big Bang itself, but as for energy generation and especially for manipulation of spacetime, they'll be well beyond any technological means of manipulation. Black holes produced by the LHC will almost immediately decay (and are probably created and decay in the upper atmosphere regularly) and larger ones just bend spacetime too much to escape from beyond the event horizon. What's past there doesn't matter for space exploration, we'll never get out again (and remember, in relativistic space, time stops to an outside observer at the event horizon).