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Chemotargets
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Looking forward to an exciting 2017!

Chemotargets has celebrated its 10th anniversary this year. It's been an exciting year for the company with the consolidation of its flagship software, CT-link, that allows for connecting off-target pharmacology, drug safety, and metabolite generation in a fully integrated platform-independent user-friendly manner. The quality and usefulness of our software in drug discovery is supported by a growing client pool in big pharma, small and medium biotech, and academic institutions worldwide.

We have seen also an increasing interest by investors in the future developments of the company. In this respect, 2017 will see the first version of CT-link being able to run on any device, including tablets and smartphones. With this strategic move, we hope to offer access to CT-link to a wider audience.

Have a nice and peaceful Christmas season and a wonderful entry of the New Year.

(via Jordi Mestres)

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Jordi's laptop running a CT-link job while waiting for his flight to Lisbon in BCN airport.
#CT-link
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CT-link 2017 is here: new module for Metabolite Prediction is now available

The 2017 release of CT-link is now available. It contains a number of improved graphical features from the 2016 version. For example, predicted ADME properties for the molecules are now provided. In addition, structural alerts and off-target pharmacology are now linked to both preclinical and clinical safety endpoints. Finally, it offers a new module to generate metabolites and compare their predicted target profiles with those from the original substrates, so safety liabilities from metabolite formation can be assessed. With all these new features, CT-link is now becoming a reference platform in predictive safety.
Those interested in getting a demo license, please contact us.
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Please find our latest article just published in PLoS Pathogens

In this worldwide effort against malaria and other neglected diseases, CT-link predicted that a good portion of the 400 compounds in the Malaria Box would have human GPCRs as off-targets. Subsequent in vitro tests on a panel of 23 GPCRs confirmed those predictions. All data is available as supplementary material of the paper and openly accessible in ChEMBL.

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The 2016 version of CT-link is here!

Chemotargets celebrated its 10th anniversary on March 28th, 2016. It's been 10 years since we started the road that has lead us to this exciting new release of CT-link, a state-of-the-art software for large-scale prediction and visualisation of the pharmacology and safety profiles of small molecules.

(Via Jordi Mestres)

We are delighted to inform you that our two safety papers in Chem Res Tox are both among the top read articles of the journal: our latest article on connecting in vitro pharmacology with in vivo toxicity (still an ASAP article) just entered the list of Most Read Articles in the last month: http://goo.gl/0O9sjD , while our review article on large-scale predictive drug safety is among the list of Most Read Articles in the last 12 months: http://goo.gl/zGsY7E

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The Institute of Medical Biotechnology of the Chinese Academy of Medical Sciences has acquired an academic CT-link license

by Jordi Mestres
via LinkedIn

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GSK acquires CT-link license

by Jordi Mestres
via LinkedIn

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Article featuring our technology – Predictive Drug Safety beyond Structural Alerts – was chosen for the cover in the October 2015 issue of Chemical Research in Toxicology (ACS Publications).
http://pubs.acs.org/toc/crtoec/28/10
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