Short answer is inconclusive. Many studies have focused on chronic opoid use, like in methadone addicts or chronic pain patients. There was some correlation there. But conversely some studies have shown hyperalgesic effects on "healthy" volunteers with only an acute exporure to opoids.
"Sometimes, the simplest things are the hardest to find. Out there, up there, in the atmosphere, amongst the things that fly around, are things that collide with other things and make other things. Small things crash into each other and produce other small things. The layman’s way of saying chemical reactions happen."