Although the AcrAB-family efflux pumps generally protect bacteria from such drugs, the physiological role of these efflux systems and their interplay with other cellular events are poorly explored. Viollier and Kirkpatrick show in the latest issue of Chemistry & Biology that a polarity landmark protein, TipN, protects cells from toxic misregulation of an AcrAB efflux pump through a cis-encoded nalidixic acid-responsive transcriptional repressor. Learn more in Chemistry & Biology: http://ow.ly/vMhwQ
SCIENCE BEHIND NON-SPECIFIC SCIENCE
Share your findings at Cell Symposium: Systems Approach to Metabolic Diseases. Submit your abstract today and join leading researchers discuss how Omics approaches can be exploited in an effort to understand the perturbations that take place in the pathogenesis of metabolic diseases http://ow.ly/vvLFZ
In the latest Cell Reports blog, Karin Bornfeldt shares what drew her to science with Editor Stephen Matheson. She also discusses “Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis," published last week in Cell Reports. Read the Q&A here http://ow.ly/vLuD7 and the paper here http://ow.ly/vLuMy
A study published in the journal Immunity reveals that a drug that inhibits a molecule called prostaglandin E2 (PGE2) increases survival rates in mice infected with a lethal dose of the H1N1 flu virus http://ow.ly/vEsXX
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