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Immune Targeting in Breast Cancer
ONCOLOGY; Vol. 29 No.5
By Ashley Cimino-Mathews, MD, Jeremy B. Foote, DVM, PhD, and Leisha A. Emens, MD, PhD

The immune system is active in breast cancer, playing a dual role in tumor progression and in immune surveillance. Infiltrating immune cells are both prognostic and predictive of response to standard breast cancer therapies. Breast cancer vaccines can activate and expand tumor-specific T cells, but have enjoyed minimal clinical success to date. Immune checkpoint blockade is a new approach to cancer immunotherapy, with documented clinical responses in diverse tumor types. Interest in breast cancer immunotherapy has been reignited by recent reports of objective responses in metastatic triple-negative breast cancer with both pembrolizumab (a programmed cell death protein 1 [PD-1] antagonist) and MPDL3280A (a programmed cell death ligand 1 [PD-L1] antagonist). Rational strategies for combination immunotherapy that expand and promote the trafficking of tumor-specific T cells, support their activity at the tumor site, and abrogate pathways of immune suppression within breast tumors are most likely to result in objective responses that translate into long-term disease control and cure.

http://www.cancernetwork.com/oncology-journal/immune-targeting-breast-cancer?cid=G
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Multimodal Screening Method Doubled Ovarian Cancer Detection
The use of an ovarian cancer risk algorithm that incorporated serum cancer antigen 125 (CA-125) screening was able to double the number of invasive epithelial ovarian or tubal cancers detected, according to the results of a study of the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) published in the Journal of Clinical Oncology.

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http://www.cancernetwork.com/ovarian-cancer/multimodal-screening-method-doubled-ovarian-cancer-detection?cid=G
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Examining the Obesity-Cancer Connection
Although obesity is considered a risk factor for developing cancer, it is also associated with a worse prognosis and an increased risk for recurrence for those that have cancer. This was a topic of discussion at the Oncology Nursing Society's (ONS) 40th Annual Congress meeting in Orlando, Florida, April 23-26, 2015. Image © sunabesyou / Shutterstock.com

http://www.cancernetwork.com/ons-2015/examining-obesity-cancer-connection?cid=G
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SBRT Offers Short-Term Improvements Over Surgery in Early-Stage NSCLC
Though surgery is the standard treatment for early-stage non–small-cell lung cancer (NSCLC), a new study suggests that stereotactic body radiotherapy (SBRT) offers lower immediate mortality and toxicity. Over the longer term, however, there is benefit with surgery over SBRT.

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http://www.cancernetwork.com/lung-cancer/sbrt-offers-short-term-improvements-over-surgery-early-stage-nsclc?cid=G
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Most Early Breast Cancer Patients Avoid Full Lymph Node Removal
Most women with early-stage breast cancer now have sentinel node biopsy (SNB) as opposed to axillary lymph node dissection (ALND), consistent with recommendations based on clinical trials, according to results of a study published in the Journal of the American College of Surgeons. This represents a major change in the clinical management of breast cancer. Image © Blamb / Shutterstock.com

http://www.cancernetwork.com/breast-cancer/most-early-breast-cancer-patients-avoid-full-lymph-node-removal?cid=G
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If the healthcare community is able to meet the National Colorectal Cancer Roundtable’s goal of increasing uptake of colorectal cancer screening in the United States to 80% by 2018, a new study estimates that 280,000 new cancer cases and 200,000 cancer deaths could be averted within 20 years.

According to a study published in the journal Cancer, only 58% of US adults aged 50 to 75 years received guideline-recommended colorectal screening in 2013. The National Colorectal Cancer Roundtable, a national coalition of public, private, and voluntary organizations, recently announced an effort to increase this rate of screening to 80%, a 22% increase, by 2018.

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Read more:
http://www.cancernetwork.com/colorectal-cancer/increased-screening-may-decrease-incidence-mortality
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Form of Vitamin B3 Reduced Non-Melanoma Skin Cancer Occurrence
The use of nicotinamide, a form of vitamin B3, reduced the incidence of non-melanoma skin cancers by 23% among a group of high-risk patients, according to the results of the Australian ONTRAC study presented today at a presscast ahead of the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting.
http://www.cancernetwork.com/asco-2015/form-vitamin-b3-reduced-non-melanoma-skin-cancer-occurrence?cid=G
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Nipple-Sparing Mastectomy as Safe as More Radical Surgeries
A large meta-analysis that included 5,276 patients found that mastectomies that preserve the nipple plus an envelope of breast skin are as safe as surgeries that remove even more tissue. The results of the study were presented at the 16th Annual Meeting of the American Society of Breast Surgeons (ASBS), held April 29–May 3, in Orlando, Florida.

http://www.cancernetwork.com/breast-cancer/nipple-sparing-mastectomy-safe-more-radical-surgeries?cid=G
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Vaccinating Boys Against HPV Proves Cost-Effective
Vaccinating adolescent boys against the human papillomavirus (HPV) may be cost-effective in the prevention of oropharyngeal cancer, according to the results of a study published in Cancer. Image © Sherry Yates Young / Shutterstock.com

http://www.cancernetwork.com/head-neck-cancer/vaccinating-boys-against-hpv-proves-cost-effective?cid=G
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Small Benefit of Follow-Up Imaging in DLBCL Comes With High Costs
The use of routine follow-up imaging with CT or PET/CT to monitor asymptomatic patients with diffuse large B-cell lymphoma (DLBCL) resulted in little survival benefit and substantial economic cost, according to the results of a recently published cost-effectiveness analysis.

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http://www.cancernetwork.com/hematologic-malignancies/small-benefit-follow-imaging-dlbcl-comes-high-costs?cid=G
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Lymph Node Staging in Localized Breast Cancer

Cancer Network: Dr. Dominici, could you describe what the current guidelines recommend for lymph node dissection in breast cancer patients?

Dr. Dominici: Certainly. For women with clinically node-negative breast cancers, the evaluation of the axillary nodes with a sentinel lymph node biopsy has really become the standard of care. Sentinel node evaluation continues to provide the necessary staging information and informs the clinical decision-making while sparing many women the morbidities of an axillary lymph node dissection. For women with clinically node-positive breast cancers, however, the axillary lymph node dissection remains the standard of care.

http://www.cancernetwork.com/podcasts/lymph-node-staging-localized-breast-cancer?cid=G
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Interesting podcast on improving quality of life with yoga!
 
It’s common for cancer patients to experience stress and anxiety during cancer treatment. One thing that can help ease those cancer treatment symptoms is sleep yoga. Also called yoga nidra, this type of yoga helps patients slow down their minds and relax, says Smitha Mallaiah, a mind/body intervention specialist in Integrative Medicine at The University of Texas MD Anderson Cancer Center.

Listen to this podcast to learn more about sleep yoga: http://bit.ly/1ES2tkK #yoga #sleepyoga #yoganidra #cancertreatment #cancer #cancersideeffects #stress #anxiety #endcancer
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Cancer Network provides research and opinion on the screening, early detection, diagnosis, treatment, and prevention of cancers.
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Through a variety of clinical, educational, and practice management tools, Cancer Network is designed to meet the informational needs of today's busy cancer care specialist.

Offering an array of clinical content highlighting the latest research, updates from important medical meetings, CME opportunities, and access to the Cancer Management Handbook, Cancer Network is considered to be a leading source of information among the community of cancer care clinicians.