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Fascinating!
 
Head and Neck Cancer: Building the Evidence Base for Precision Oncology http://1.usa.gov/1JeEYGU
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Esophageal Reflux in 54-Year-Old Patient

A 54-year-old man with symptoms of esophageal reflux is found to have a small nodule in the esophagus.

What is your diagnosis?

A. Adenocarcinoma
B. Squamous cell carcinoma
C. Granular cell tumor
D. Esophagitis

http://www.cancernetwork.com/image-iq/esophageal-reflux-54-year-old-patient?Cid=G+
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Palpable Nodule in Testicle of Young Man

A 27-year-old man presents to his primary care physician, complaining of a palpable nodule in his right testicle. He has no other symptoms. Gray-scale and color Doppler ultrasound images are shown below.

What is your diagnosis?
A. Focal fat
B. Testicular cancer
C. Testicular cyst
D. Orchitis

http://www.cancernetwork.com/image-iq/palpable-nodule-testicle-young-man?cid=G+
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COMPLETE REMISSION for Hannah! We celebrate with you.

PS - we love the shirt! #myoncologistismyhomeboy
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Mass Found in Nasopharynx of 54-Year-Old Patient

A 54-year-old man is found to have a nasopharyngeal mass.

What is your diagnosis?
A. Melanoma
B. Rhabdomyosarcoma
C. Leiomyosarcoma
D. Nasopharyngeal carcinoma

http://www.cancernetwork.com/image-iq/mass-found-nasopharynx-54-year-old-patient?cid=G+
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Nice picture.
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Ponatinib Shows Promise in CML Even After Early Trial Termination

Despite the early termination of a phase III trial due to safety concerns, an analysis suggests that ponatinib offers improved efficacy over imatinib in patients with newly diagnosed chronic-phase chronic myeloid leukemia (CP-CML). That improvement comes at the expense of higher rates of adverse events, according to the EPIC trial.

EPIC was a multinational, multicenter, randomized, open-label trial. It included 307 patients, with a median follow-up of only 5.1 months. The trial was terminated in October 2013 after a signal for increased risk of arterial thrombotic events was observed in the ponatinib treatment arm. Because of that early termination, none of the predefined endpoints could be thoroughly analyzed, but researchers presented other relevant data based on a cutoff of April 1, 2014. The analysis, led by Jeffrey H. Lipton, MD, PhD, of Princess Margaret Cancer Centre at the University of Toronto in Canada, was presented at the American Society of Hematology Annual Meeting in San Francisco in December 2014.

http://www.cancernetwork.com/chronic-myeloid-leukemia/ponatinib-shows-promise-cml-even-after-early-trial-termination?cid=G+
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10 Ways Doctors and Patients Can Avoid Hating Each Other

Patients appreciate punctuality, but there are unexpected situations that can set you back. I always apologize for a wait. Please accept my apology graciously. However, if someone makes you wait an unacceptable period every time you have an appointment, I think you are foolish to stay with that provider. If you have no respect for your time, neither will he/she. Likewise, do not wander in 15 minutes late for your appointment and think that does not cause havoc for the rest of my day. And if you are not coming, please call and cancel.

http://www.cancernetwork.com/blog/10-ways-doctors-patients-can-avoid-hating-each-other?cid=G
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Smokers Have Worse Prostate Cancer Outcomes

Prostate cancer patients who smoke may be more susceptible to complications from their treatment, and at increased risk of side effects and disease recurrence, according to a new study.

Patients who were current smokers had a 40% relative increase of cancer relapse and were twice as susceptible to disease spread and death due to prostate cancer compared with their non-smoking counterparts. The results are published in BJU International.

"Less optimal tumor control outcomes among smokers could possibly be explained by the influence of less oxygen concentration within the treated tumors among smokers, which is known to lead to less sensitivity of the cells being killed off by radiation treatments," said study author Michael Zelefsky, MD, of the Memorial Sloan Kettering Cancer Center, in a statement. "Our findings point to the importance of physicians counseling their patients regarding the potential harms of smoking interfering with the efficacy of therapies and for increased risks of side effects."

http://www.cancernetwork.com/prostate-cancer/smokers-have-worse-prostate-cancer-outcomes?cid=G+
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Ann Fonfa's profile photoZeezee Agapotheos's profile photo
 
Smoking seems to negatively/BADLY impact so many health challenges. It is worth stopping.  It is possible.  All of us who have done so, thought that it was hard or even impossible.  BUT nothing is impossible with focus.  Use whatever tools work - I chewed gum, straws, toothpicks, etc.  I wrapped the pack and hid it in my drawer.  I did not allow myself to start earlier than 10AM or smoke after 9PM.  Little by little, within TWO weeks I was well on my way to stopping.  (1974).
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Heart Mass Discovered in 47-Year-Old Woman

A 47-year-old woman is found to have a mass in the left atrium of her heart.

What is your diagnosis?
A. Rhabdomyoma
B. Liposarcoma
C. Myxoma
D. Paraganglioma

http://www.cancernetwork.com/image-iq/heart-mass-discovered-47-year-old-woman?cid=G+
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ADT Risks and Side Effects in Advanced Prostate Cancer: Cardiovascular and Acute Renal Injury

Androgen deprivation therapy (ADT) is key to the treatment of men with advanced prostate cancer. ADT can consist of surgical (bilateral orchiectomy) or medical strategies (eg, luteinizing hormone–releasing hormone agonists or gonadotropin-releasing hormone [GnRH] antagonists). The substantial reduction of testosterone levels achieved with ADT is associated with numerous well-characterized side effects, the management of which are key to patients’ quality of life. More recently, a group of metabolic changes (dyslipidemia, hyperglycemia, others) that carry an increased risk of diabetes and cardiovascular disease have been reported in men receiving ADT. We review recent evidence suggesting an increased risk of pneumonia, cardiovascular disease, and acute kidney injury in men treated with ADT and consider whether the incidence of such events differs with the treatment modality. We discuss possible mechanisms by which such events might be mediated, including the roles of testosterone and the GnRH receptor, and consider current guidelines in light of these data.

http://www.cancernetwork.com/oncology-journal/adt-risks-and-side-effects-advanced-prostate-cancer-cardiovascular-and-acute-renal-injury?cid=G+
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Metabolic Syndrome Linked to Higher Endometrial Cancer Risk

Women with metabolic syndrome who are age 65 or older have an increased risk of endometrial cancer, according to the results of a new study published in Cancer Epidemiology, Biomarkers & Prevention. The increased risk was found regardless of whether a woman was also overweight or obese.

Metabolic syndrome is marked by a combination of different medical conditions: low levels of high-density lipoprotein (HDL), the so-called ‘good’ component of cholesterol, and high levels of circulating triglycerides.

Metabolic syndrome, as defined by the US National Cholesterol Education Program Adult Treatment Panel III criteria, was associated with a 39% increased risk of endometrial cancer, or a 21% increased risk after taking into account whether a woman was obese or overweight.

http://www.cancernetwork.com/endometrial-cancer/metabolic-syndrome-linked-higher-endometrial-cancer-risk?cid=G+
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