I don't know about that. You do need iTunes to first create your iTunes Store account. After that, you don't really need iTunes. And to be clear, going totally wireless is not baked into iOS, but who uses only the default apps anyway. What would be the point of never buying any apps and only using the ones that came with the phone when you bought it.
iOS 5 brought with it iOS updates OTA (as long as it is charging). All of the content that I use (movies, music, audiobooks, podcasts, files, everything is pulled down using my preferred apps. And content goes back using various apps also.
Files = Dropbox, SugarSync, etc
Podcasts = Downcast
Music = Spotify, Google Music, Amazon Cloud Player
Movies = (I forget right now.)
Audiobooks = Audible
Is this solution native? No. So what. I am tether-free and iTunes-free forever. Charge and go.