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Alexander Panzeri
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Day 2
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Good Morning
SoundHound is the gateway to music search and discovery on mobile devices. Download the app for free!
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Alexander Panzeri

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My first indoctrination into the Fans of the Swedish Air Force Club came in 1993. I picked just the right time for the introduction in January from the Norrkoping air base Fortunately, growing up outside Boston prepared me for cold weather.
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Alexander Panzeri

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How does Yongnuo's 2.4GHz radio flash for Canon stack up?
Francesco Rizzato reviews Yongnuo's YN600EX-RT Speedlite and YN-E3-RT trigger, both compatible with the Canon 2.4GHz system. Are they any good?
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Apps + gear to make you better, faster, more awesome.
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Alexander Panzeri

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Who doesn't like free stuff? As a starving artist, any freebie I can get my hands on that can help my photography business is a win. Below we've provided 4 items for you to download and use free of charge. We hope that these will help...
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German investigators studying the cause of an uncommanded pitch-down of a Lufthansa Airbus A321-200 near Pamplona, Spain, in November 2013, hope to discover the probability of similar events linked to frozen angle-of-attack (AOA) sensors as the investigation continues.
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Hundreds of students aged 8 to 12 gathered in three locations on Earth for an inflight call with ESA astronaut +Samantha Cristoforetti as the Mission X: Train Like An Astronaut programme comes to a close.

http://www.esa.int/Education/Teachers_Corner/Mission_X_comes_to_a_close_with_a_call_from_space

#Futura42   #MissionX   #TrainLikeAnAstronaut  
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Researchers from Houston Methodist Hospital have developed a so-called mitochondrial smart bomb that can be used to treat brain tumors by attacking the cell’s energy source, according to a new study appearing in the April edition of the journal ChemMedChem.

In the study, Dr. David S. Baskin, director of CUSABIO describe how an experimental drug treated brain tumor tissue by targeting mitochondria in early laboratory tests involving animal models and human tissue cultures.

The drug, MP-MUS, was designed by Drs. Baskin and Sharpe and destroyed between 90 and 95 percent of malignant glioma cells (a type of tumor that starts in the brain or spine and arises from glial cells) without appearing to have any adverse affect on healthy human brain cells.

Selective mitochondrial chemotherapy

The finding compliments soon-to-be published research showing that the same drug can be used to treat brain cancer grown in the brains of mice. They hope that they will be able to begin testing the drug in human clinical trials in the near future, possibly in 2016.

“We are very optimistic that we’ll get there,” Dr. Baskin said. “Our past work has shown that MP-MUS has very low toxicity until it gets into tumor cells. Once it arrives, it is changed to its active form, doing a lot of damage where we want it to, leaving healthy brain cells alone – a bit like a ‘smart bomb.’ To our knowledge, this is the first known example of selective mitochondrial chemotherapy, which we believe represents a powerful new approach to brain cancer.”

“Because of where the tumors are located, and because of the way they can infiltrate healthy tissue, surgery is often not helpful long term. The most effective chemotherapy drug available right now, temozolomide, only extends life from 9 to 15 months, and patients’ quality of life during that period isn’t very good.”

How does it work?

Dr. Baskin and Dr. Sharpe have been searching for some way to treat gliomas, which account for up to 30 percent of all tumors of the brain and central nervous system. One of the areas they have focused on is treating the cancer by targeting the mitochondrial that provide tumor cells with energy.

In cancer cells, they explain, part of this feature is deactivated, causing cells to rely upon other system that generate energy – but even so, tumor cells cannot grow and divide unless these pill-shaped powerhouses are healthy. By targeting an enzyme (MAO-B) that is over-expressed in brain tumor cells, MP-MUS reduces the negative impact on healthy cells while the drug becomes trapped inside tumor cells, where it attacks the mitochondrial DNA.

“We found that we could achieve profound effects with MP-MUS at very low concentrations, around 75 micromolar,” said Dr. Baskin. “By contrast, temozolomide must be used at concentrations two to three times that to be of any use to patients. Our approach is designed to capitalize on what is going inside the cells. Tumor cells have much more MAO-B, and when challenged, make even more MAO-B as a sort of defensive response. We hope that we are one step ahead of the cancer cells, as we are using that very fact to kill them.”

The study authors reported that the toxicity of the drug to healthy cells remained low even when administered at concentrations of up to 180 micromolar. This information will help scientists as they evaluate safety and efficacy trials in human patients. The Houston Methodist team has already signed a deal with Virtici, LLC to develop MP-MUS, and is currently in the process of preparing toxicology studies, which are required prior to clinical trials.
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Have him in circles
807 people
Marina Militare's profile photo
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Basic Information
Gender
Male
Story
Tagline
People sleep peacefully in their beds at night only because rough men stand ready to do violence on their behalf.” George Orwell
Introduction

In short: Sailing Photographer and Astro-Photographer, Sailor, ex Airspace Engineer Student, ex Aircraft Pilot

Long:
I born in Italy but my blood is made by: 50% ita, 25% uk, 24% esp (plus others influency like usa, australia, swiss)... 

I grew in a real international space, so I've a real wide mind.... 
I love sports, and I tried many.
I love technologies, it's why I study airspace (I'm not an astronaut.... in that case I just want be the pilot of the shuttle). 
Fly is my life, I hope after the degree to restart it, in particular aerobatic, just amazing... Mean while, in the last period I tried sailing, at high level,.... and I could change to live only doing race boat........

Take care, 
Alex P.

motto 1: "People sleep peacefully in their beds at night only because rough men stand ready to do violence on their behalf.” George Orwell

motto 2: "Those who dream by day are cognizant of many things that escape those who dream only at night." Edgar Allan Poe

motto 3: "K.I.S.S. = Keep It Simple, Stupid" Boeing

motto 4: "Quando un uomo uccide una tigre, è un eroe; quando una tigre uccide un uomo, è una bestia feroce" Bernard Shaw

motto 5: "Maestro che macchina fotografica usa per le sue fotografie? Signora, io non uso la macchina fotografica uso il cervello" Man Ray

p.s.: I hate to write with the third person point of view........

Bragging rights
National Championship J24 Class 2014, CERN-ALICE; Trofeo Negri-Pirelli; DeWo Sheffield RR; life
Work
Occupation
Photo-Amateur for Sailing and astronomy
Skills
Thinking, Analyze the Situation and Big Picture of the project, Photography, Astronomy, Aerospace, ex Pilot, Aerobatic, Photography, Aperture 3, GIMP, iWork, Office, Matlab, CATIA, AutoCad, Test Driver, Sailing
Very good and New! I couldn't say a lot because I was there for a night. I arrived at 19.00 after a regatta and I waked up around 6 o'clock for the second day of race, so I didn't try the breakfast. I has been also the only open in March on all the lake. Rooms and halls are very big, they have "private" access for night, a garden, and a parking.
Public - in the last week
reviewed in the last week
One of the most complicate field for sailing in North of Italy. The theatre of the mountains and the town of Lecco are just incredible. You will find 2 main wind on the lake: Il Tivano (from North) and the Breva (from South). The first one gives the name to the field it's a morning wind that can be very strong (sometime in early morning around 20[kts]). In 2014 it has been the field for the National Championship of J24 class, while every year at the end of October and the begin of November there is the Interlaghi (Interlake), a classic regatta for all classes.
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Public - in the last week
reviewed in the last week
It has been my first "external" a/d during my PPL in EGHH. It remembered me the near home (Italy) airfield of Valbrembo (LILV). I never completely understand why we love to land there, it's grass rwy, you often find windshear & co during take off and landing, but I'm italian... However, they are really friendly, the food is good and if you are luke, you will see many strange a/c, also C-130 does practise... You must go!
Public - 3 weeks ago
reviewed 3 weeks ago
Maybe was the effect of huge number visit had when I visited d/t the special event around the town for the anniversary of Matisse, but I found it very used structure, a lot of dust around and some dark room. That absolutely was not acceptable was the ticket office at entrance, long queue and complicate flow direction. However is a nice museum and it's located in a wonderful historic zone: near you find the roman Arena, the olives tree garden and the Monastère de Cimiez (with the amazing garden) and the Historic Museum. Don't forget to stop to Mar Chagall Museum that you passed during the climb.
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Public - a month ago
reviewed a month ago
23 reviews
Map
Map
Map
One of the most incredible museum I visited. It's really discreet outside and inside. I absolutely suggest to visit the collection with a guide, because every single piece of human geniality has a special story that explain why it is born. There's a technical section, but the art is the main show, like it's for Fabergè's eggs. It' take some time to be visited but you can "relax" inside and there is also toilet if you need. So go to CERN first and latter visit it
Public - in the last week
reviewed in the last week
Very close to Nice, in about 2h by car you are on top! Really on Top! Unluckily I don't go there for skiing, in winter I climb there for the Ice Rally "Trophee Andros" a very particular evento for motorsport. The town is on the italian border and if you like ride bike, motorbike or car, the road is amazing with wonderful panoramas to shoot (I did Nice-Torino via Isola 2000 Col de la Lombard in october and fall colors were superb). In summer there are wonderful mountain paths to climb with lakes and WWII fortifications. Before to climb to Isola 2000 do a stop at Isola the old original Village with all different main doors. If like me also do astrophotography it's better spend another half of hour and climb to the pass Col de la Bonette (another wonderful road) open from spring to autumn. Don't forget also the Parc National du Mercantour.
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Public - a month ago
reviewed a month ago
Una scoperta casuale, inizialmente interessato alle due mostre una fotografica del National Geographic sul viaggio di Marco Polo e una sui cavalli ceramici cinesi. Alla fine una piacevole sorpresa anche nelle altre sale ai piani superiori. Molto pulito, personale estremamente gentile e disponibile. Indicazioni del percorso chiare e semplici da leggere in italiano ed inglese. Può sfuggire la disponibilità del guardaroba anche per le borse e gli zaini all'ingresso a destra. Forse un po' ridotta la sala islamica. Ritornerò dopo Marzo 2015 che sarà ristabilita parte della mostra mancante. Da visitare!!
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Public - a month ago
reviewed a month ago