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Alex Fung
Lives in Happy Valley, Hong Kong
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It will be the Longest Day 

It is longer than D Day (I wonder if you have watched the 1962 movie or listened to the theme song), for today we have 86,401 seconds.
The day will officially be a bit longer than usual on Tuesday, June 30, 2015, because an extra second, or 'leap' second, will be added.
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+Sacred Geometry Decoded - Thanks.  I'll check it out later.  I need a nap!
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Hong Kong is not China.

If you can't understand Chinese, go directly to see the English infographics here:
https://www.facebook.com/localstudiohongkong/posts/911071258931191
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My trip to Hokkaido.
1/2003
The blog was long long ago, just migrated to blogspot.
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+dolma hongkong Wow you remembered. 
Basically I copy text and paste. Pictures need to reload. The tough part is re-editing, for example, to change the font and size, to re-fit several original pages into one page, but it is just a change of personal preference. And fixing a lot of typos and removing some broken links.

This blog however was not on yahoo. It was even older. It was on my personal web site and was only viewable by IE (because I only know how to write program for IE).
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用貼圖來黎討論投票策略,既方便又快捷
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建制派議員以WhatsApp通訊,但並未令投票更加協調,更在表決時出現「大奇跡日」。未知是否香港政治人物普遍上了年紀,不擅科技加上老花而產生混亂﹐還有內鬼將WhatsApp通訊內容轉交傳媒。來自韓國的Line也加入炒花生,嘲笑建制派,並突出該軟件有多款表情sticker的特點,表示「用貼圖來黎討論投票策略,既方便又快捷」。
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+David Lazarus If you know what happened in the Legislative Council last week, you would understand. Or you can google HK news for that.
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Smart Insulin

One dose of Ins-PBA-F regulates blood sugar levels for up to 14 hours.
 
Smart Insulin - New Hope for Type 1 Diabetes patients 

Type 1 Diabetes patients are required to inject specific dosage of insulin dependent on blood sugar level. The miscalculation of insulin can lead to life threatening hypo/hyperglycemia. Scientist at university of Utah have developed Ins-PBS-F, a long-lasting "smart insulin." 
Phenylboronic acid (PBA) works as regulatory mechanism in Ins-PBA-F,at low blood sugar levels, PBA interacts with plasma and block insulin activity but as sugar level in blood increases PBA bind to sugar molecules and release active insulin. Study published in PNAS shows that one dose of Ins-PBA-F regulates blood sugar levels for up to 14 hours in mice. This is first in class insulin as other smart insulin techniques use biomaterials to control insulin release. 
"Ins-PBA-F fits the true definition of 'smart' insulin, where the insulin itself is glucose responsive. It is the first in its class." Dr.Chou (co-author)

PNAS study abstract: http://www.pnas.org/content/early/2015/02/04/1424684112.abstract

Sources : Eurekalert ( http://ow.ly/IQgWH ) BBC (http://ow.ly/IRUGT )

#dibetes #type1dibetes #bloodsugarlevel #smartinsulin #hope
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A second pair of lions at HSBC (150 anniversary)
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Cony and Brown in Ocean Park
 
海洋公園夏水禮來了!今年更聯同一眾超人氣LINE FRIENDS,於全亞洲首個LINE主題玩水派對盡情玩轉十大至COOL玩水亮點,場內有第一次登陸香港的「動感水韆鞦」、拍照熱點「超級大水桶」、高達三層樓的「瘋狂滑水梯」、「勁爆水彈陣」及「幻彩噴泉陣」等激FUN設施,更可於「狂野泡泡派對」內勁舞狂歡!另有夏日限定店LINE Pop-Up Store推出超過60款全港首賣的獨家LINE精品,粉絲可盡情購入心水商品,今個夏天記得到海洋公司享受澎湃冰涼快感!
海洋公園夏水禮
日期:7月1日至8月31日
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Looking for a diet that will help you burn fat? 
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+cocker dunn Probably no, add some chili to your curry.
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Lexus Hoverboard, Back to the Future
<em>Back to the Future</em> fans may finally get to try a real, live version of the film's famous floating skateboard
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Wish it was Honda instead. :^/
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US finally drops cholesterol intake warning

After making unfounded claims about cholesterol for decades, the US Government finally reverts the Dietary Guidelines against cholesterol intake. 

+Cynthia Bush 
Every five years, the United States government updates a set of Dietary Guidelines intended to help its citizens make healthier food choices. These guidelines also help inform how companies package...
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Medicine  - 
 
Fixing Microglia may cure Alzheimers

Experiments show that keeping Microglia on the right track counters memory loss and preserves healthy brain physiology.
 
Advancement in the Study of How Alzheimers Works

You might have seen the media headlines, “Stanford Researchers discover Cure for Alzheimers”.  As always with this kind of research, it is not quite that dramatic.  But researchers at Stanford University School of Medicine have made some breakthroughs in learning how Alzheimers works and possible ways to counteract this horrible disease.  

Brain cells called microglia chew up toxic substances and cell debris, calm inflammation and make nerve-cell-nurturing substances. New research shows that keeping them on the job may prevent neurodegeneration.  ⓐ

The mass die-off of nerve cells in the brains of people with Alzheimer’s disease may largely occur because an entirely different class of brain cells, called microglia, begin to fall down on the job, according to a new study by researchers at the Stanford University School of Medicine.  ⓐ

The researchers found that, in mice, blocking the action of a single molecule on the surface of microglia restored the cells’ ability to get the job done — and reversed memory loss and myriad other Alzheimer’s-like features in the animals.  ⓐ

The study, published online Dec. 8 in The Journal of Clinical Investigation, illustrates the importance of microglia and could lead to new ways of warding off the onset of Alzheimer’s disease, which is predicted to afflict 15 million people by mid-century unless some form of cure or prevention is found. The study also may help explain an intriguing association between aspirin and reduced rates of Alzheimer’s.  ⓐ

“Microglia are the brain’s beat cops,” said Katrin Andreasson, MD, professor of neurology and neurological sciences and the study’s senior author. “Our experiments show that keeping them on the right track counters memory loss and preserves healthy brain physiology.”  ⓐ

A microglial cell serves as a front-line sentry, monitoring its surroundings for suspicious activities and materials by probing its local environment. If it spots trouble, it releases substances that recruit other microglia to the scene, said Andreasson. Microglia are tough cops, protecting the brain against invading bacteria and viruses by gobbling them up. They are adept at calming things down, too, clamping down on inflammation if it gets out of hand. They also work as garbage collectors, chewing up dead cells and molecular debris strewn among living cells — including clusters of a protein called A-beta, notorious for aggregating into gummy deposits called Alzheimer’s plaques, the disease’s hallmark anatomical feature.  ⓐ

The Stanford study provides strong evidence that this deterioration in microglial function is driven, in large part, by the heightened signaling activity of a single molecule that sits on the surface of microglial and nerve cells. Previous work in Andreasson’s lab and other labs has shown that this molecule, a receptor protein called EP2, has a strong potential to cause inflammation when activated by binding to a substance called prostaglandin E2, or PGE2.  ⓐ

.  .  .  the neuropathological features implicated in Alzheimer’s was borne out in subsequent experiments for which Andreasson’s team used mice genetically predisposed to get the mouse equivalent of Alzheimer’s, as well as otherwise normal mice into whose brains the scientists injected either A-beta or a control solution. In both groups of mice, the expected deleterious effects on memory and learning didn’t arise if EP2 within microglial cells was absent, as a result of a genetic manipulation. Blocking microglial EP2 activity significantly improved these animals’ performance on two kinds of standard memory tests: one that assesses how quickly a mouse forgets that it has encountered an object before, and another that rates the mouse’s ability to remember where a food reward is in a maze.  ⓐ

Although PGE2 is known to regulate inflammatory changes in the brain, it exercises diverse, useful functions in different tissues throughout the body, from influencing blood pressure to inducing labor. Complicating matters, PGE2 is just one of five different prostaglandins originating from the precursor molecule produced by COX-1 and COX-2. So aspirin and other COX-1- and COX-2-inhibiting drugs may have myriad effects, not all of them beneficial. It may turn out that a compound blocking only EP2 activity on microglial cells, or some downstream consequences within microglial cells, would be better-suited for fending off Alzheimer’s without side effects, said Andreasson. Meanwhile, her group is exploring the biological mechanisms via which PE2 signaling pushes microglia over to the dark side.  ⓐ

Hopefully this new research will help in preventing and maybe even reverse some of the damage to the brain.  Not a cure yet but a really big breakthrough in understanding how Alzheimers does its damage.  

Tip of the hat to +Kimberly Chapman and +Kyla Myers  for first sharing this news.  Thanks.


ⓐ  Stanford Medicine News Center
Blocking receptor in brain’s immune cells counters Alzheimer’s in mice, study finds
http://med.stanford.edu/news/all-news/2014/12/blocking-receptor-in-brains-immune-cells-counters-alzheimers.html

 ⓑ The Journal of Clinical Investigation  (open access)
Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models
http://www.jci.org/articles/view/77487

Image: From the Research Paper
Basal EP2 signaling in healthy microglia regulates normal homeostatic effects on cell cycle, cytoskeletal, and immune functions (Supplemental Figure 3D) and maintenance of healthy synapses (yellow). With aging and/or Aβ42 accumulation, microglial EP2 signaling is upregulated, increasing proinflammatory gene expression and suppressing beneficial chemokine production and chemotaxis, Aβ clearance, nuclear hormone PPARγ signaling, and IGF1/AKT signaling. A major target upregulated by EP2 is COX-2 (Supplemental Figure 3B), which drives additional PGE2 production, perpetuating toxic EP2 inflammatory signaling. In combination, these EP2 regulated effects contribute to synaptic degeneration (gray) and functional memory impairment
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Meh To
 
Soon Alzheimer's will be a thing of the past for smart people
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Happy Valley, Hong Kong
Story
Tagline
馮浩山 working in the IT field a quarter of a century.
Introduction
Published the best game guide for Looking Glass Studios Thief (Thief Dark Project / Thief Gold and Thief II).

Published a method to restore the Rubik's Cube that does not remember any arbitrary sequences, and as a result I can still do it after 15 years not touching a cube.

Published a French poem on the Paroles magazine of Alliance Française de Hong Kong -- normally student articles only appear in their Paroles Étudiants student magazine.

My PDAs:
  • Palm V
  • HP PPC 2002
  • HP PPC 2003
  • Dopod WM5
  • HTC HD2 WM6.5, Android Gingerbread
  • Samsung Galaxy Note Android Gingerbread - Jelly Bean
My favorite TV programmes:
  • Better off Ted
  • Doll House
  • Fringe
  • Doctor Who
  • The Big Bang Theory
  • 山おんな壁おんな (山女壁女)
  • 雪之女王

My favorite anime:
  • Ranma 1/2 
  • Dragon Ball
  • Neon Genesis Evangelion
  • 涼宮春日的憂鬱
Bragging rights
Have been tolerating the HKSAR Government together with the people of Hong Kong.
Work
Occupation
Information Technology
Basic Information
Gender
Male
Other names
馮浩山, Fung Ho San
好味又抵食
Public - a year ago
reviewed a year ago
菠蘿包又大又好食, 不過片牛油好細, 簡直感覺唔到。
Public - a year ago
reviewed a year ago
The signature dish cheese spaghetti is really good. Actually everything we ate was tasty. The soup, the salad and the desert. The mall it is in is a bit out of the way and looks deserted.
Public - a year ago
reviewed a year ago
抹茶雪糕非常好味(註: 抹茶雪糕和綠茶雪糕是完全不同的)。 抹茶latte 也非常好。 以前以為綠茶加奶會很怪, 在日本茶室試過才知道是很好味的。
Public - a year ago
reviewed a year ago
37 reviews
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A limited but unusual choice of dishes on the menu. Dishes are not large, but delicious. Last order 22:30.
Food: GoodDecor: GoodService: Very Good
Public - a year ago
reviewed a year ago
仔粥好食, D好正。
Public - a year ago
reviewed a year ago
Best tonkatsu in Hong Kong. Monday to Friday also offers lunch set at half of regular price!
Public - a year ago
reviewed a year ago