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Able Lawrence
Works at SGPGIMS
Attended SGPGIMS
Lives in Lucknow
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Able Lawrence

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Common grass yellow butterfly. 
For more on butterflies follow https://plus.google.com/collection/83L9b
Able Lawrence originally shared to Butterflies:
 
Common grass yellow Eurema hecabe 
A bright yellow butterfly found in Asia and Africa where it is known simply as grass yellow, it flies low over the ground in grass and scrub. Its color shade varies with season with darker shade during long days and lighter shade during shorter days. Its apex of the forewing (upper side, not seen) is black while the underwing (in picture) has a lighter shade of yellow than upper side. 
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It's other name should be sunshine. These are almost always around and are so beautiful. Thanks for sharing! +Able Lawrence :) The collection is amazing as well!
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Able Lawrence

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Electron-Ion Collider plans to smash high energy electrons with protons or heavy ions, hoping to probe the structure of protons in greater detail 
Proposed US electron–ion smasher wins endorsement from influential nuclear-science panel.
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+Keith Pollock For Americans it seems they have to feel threatened. If they are they can literally put people in the moon. 
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Able Lawrence

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Colombia University researchers led by Latha Venkataraman developes the first single molecule electronic device
Single-molecule diodes with high rectification ratios through environmental control #MolecularElectronics  
Molecular electronics aims to miniaturize electronic devices by using subnanometre-scale active components. A single-molecule diode, a circuit element that directs current flow4, was first proposed more than 40 years ago5 and consisted of an asymmetric molecule comprising a donor–bridge–acceptor architecture to mimic a semiconductor p–n junction. Several single-molecule diodes have since been realized in junctions featuring asymmetric molecular backbones, molecule–electrode linkers or electrode materials. Despite these advances, molecular diodes have had limited potential for applications due to their low conductance, low rectification ratios, extreme sensitivity to the junction structure and high operating voltages. Here, we demonstrate a powerful approach to induce current rectification in symmetric single-molecule junctions using two electrodes of the same metal, but breaking symmetry by exposing considerably different electrode areas to an ionic solution. This allows us to control the junction's electrostatic environment in an asymmetric fashion by simply changing the bias polarity. With this method, we reliably and reproducibly achieve rectification ratios in excess of 200 at voltages as low as 370 mV using a symmetric oligomer of thiophene-1,1-dioxide. By taking advantage of the changes in the junction environment induced by the presence of an ionic solution, this method provides a general route for tuning nonlinear nanoscale device phenomena, which could potentially be applied in systems beyond single-molecule junctions
http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2015.97.html
Under the direction of Latha Venkataraman, associate professor of applied physics at Columbia Engineering, researchers have designed a new technique to create a single-molecule diode, and, in doing so, they have developed molecular diodes that perform 50 times better than all prior designs. Venkataraman's ...
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What kind of future applications this could have?
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Irreproducibility - Are antibodies to blame? 
Many a promising breakthrough have been forgotten in time due to lack of reproducibility and blames have been placed on reasons from methodology to poor laboratory practice or worse but it could also be due to variations in antibodies. Antibodies are more than just proteins and carbohydrate residues on them (glycosylation) plays an important role in antibody functions and manufacturing methods and even batch variation can affect glycosylation and function. This much had become apparent following the debate over biosimilar drugs. (After original innovators critcised the generic biosimilars, it turned out that even the different batches from innovators were widely different).  There is increasing evidence that lack of specificity of antibodies (they might find something other than they were supposed to bind) could be a serious problem. 
Antibodies are the workhorses of biological experiments, but they are littering the field with false findings. A few evangelists are pushing for change.
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Well pathogens for the least, can readily blame on antibodies the non-reproducibility of infections.
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Able Lawrence

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Life Sciences collection 
I have organized my Life Sciences posts into a collection, the googles implementation of subject based channels. Now you can selectively follow (or even get notified by opt in) my posts category wise. 
There are other collections too such as Healthcare and Medicine, Ecology and Wildlife, Gravitation and Cosmology, besides the popular Birds and Butterflies 
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+Vladlen Nikulin I am planning to shift more and more of my postings to collections rather than post publicly and then shift. I basically want to encourage people to follow collections individually so I can post each category freely, holding back nothing. 
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Able Lawrence

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Common Jezebel Delias eucharis 
A brightly colored (and poisonous) butterfly that is widespread in South and South Asia which can be seen anywhere except the arid areas. Unlike most butterflies, this one has a bright underside and dull upper side. This is so because, it flies high in the canopy only to come down for feeding nectar, so as to signal to birds (about danger) flying below. 
As can be expected, another butterfly Painted sawtooth is a close Batesian mimic (where the mimic gains protection by being a look-alike of a poisonous and bright butterfly) 
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Kya ho rha h..
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Common sailor butterfly Neptis hylas 
Widespread in south and south-east Asia, this nymphalid butterfly has a stiff gliding flight due to the shallow wing beats just above horizontal. 
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Nice ...
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Would the world have been a better place, a more liberal world, minus the world wars that followed if the battle of Waterloo never took place. An apology for Napoleon on the eve of the bicentenary of his last battle. 
 
"[...]  That night Napoleon sat down to eat the dinner that had been cooked for Louis XVIII, who had fled Paris only hours earlier. Not one shot had been fired in the Bourbons’ defense. “Never before in history,” said Parisian wags, “has an emperor won an empire simply by showing his hat.” [...]"
On the bicentennial of the most famous battle in world history, a distinguished historian looks at what could have been
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I still don't get the title though. None of it argues the title, excepting the last paragraph. As if after all that discussion of history, such a conclusion was obvious.
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Is Alzheimers the price of intelligence?
Humans are the only animals that get Alzheimers disease and was it a mere coincidence that the genes linked to it are the same ones that might have given us that extra intelligence. A study that compared variability among humans from different continents suggest that these genes were under strong selection from 200,000 - 50,000 years ago, the time when the brains and intelligence of our ancestors evolved rapidly.  _A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years_   #dementia   #alzheimer   #evolution  
http://biorxiv.org/content/early/2015/05/05/018929
Factors that drove evolution of intellectual capacity also implicated in memory disorder.
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Able Lawrence

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Common grass yellow Eurema hecabe 
A bright yellow butterfly found in Asia and Africa where it is known simply as grass yellow, it flies low over the ground in grass and scrub. Its color shade varies with season with darker shade during long days and lighter shade during shorter days. Its apex of the forewing (upper side, not seen) is black while the underwing (in picture) has a lighter shade of yellow than upper side. 
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A beautiful picture of a beautiful butterfly.
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Indian peafowl male dancing Pavo cristatus 
Male peacocks dance to attract mates and I wanted to get a good picture for a long time (always, the view was partially obscured or had wrong background). Finally got lucky today to get a frame covering shot. The image was overexposed by two stops and then down processed giving the vivid details. [The correctly exposed image didnt have details] 
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Beautiful photo!!+Able Lawrence..
From now good night and sweet dreams.💤😴
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Normal skin harbours accumulates mutations in cancer genes 
Cancer is a multistep process (orignally described in colon cancer) where multiple sequential mutation lead to genomic instability and uncontrolled cell growth. But how common are these mutations in normal tissues? 
This study looked at somatic mutations in 74 cancer associated genes from multiple samples of normal skin from four normal healthy individuals and found that normal skin carries a large number of such mutations. The burden of mutations was quantitatively similar to cancer tissue. More over, these mutations seemed to be under positive selection. This shows that cancer arises from a continuum of accumulating mutations in otherwise normal behaving tissues and combination of mutations and other factors tip the balance in a stochastic manner. Now we have to wait for more studies in other tissues capable of self renewal and continued replication such as immune cells and other mucosal cells. 
High burden and pervasive positive selection of somatic mutations in normal human skin
Abstract: How somatic mutations accumulate in normal cells is central to understanding cancer development but is poorly understood. We performed ultradeep sequencing of 74 cancer genes in small (0.8 to 4.7 square millimeters) biopsies of normal skin. Across 234 biopsies of sun-exposed eyelid epidermis from four individuals, the burden of somatic mutations averaged two to six mutations per megabase per cell, similar to that seen in many cancers, and exhibited characteristic signatures of exposure to ultraviolet light. Remarkably, multiple cancer genes are under strong positive selection even in physiologically normal skin, including most of the key drivers of cutaneous squamous cell carcinomas. Positively selected mutations were found in 18 to 32% of normal skin cells at a density of ~140 driver mutations per square centimeter. We observed variability in the driver landscape among individuals and variability in the sizes of clonal expansions across genes. Thus, aged sun-exposed skin is a patchwork of thousands of evolving clones with over a quarter of cells carrying cancer-causing mutations while maintaining the physiological functions of epidermis. #cancer  
http://www.sciencemag.org/content/348/6237/880.abstract
Image courtesy http://www.cancer.gov/types/skin/patient/skin-treatment-pdq
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Excellent share Able Lawrence :-)
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Work
Occupation
Doctor; Rheumatology and Clinical Immunology
Skills
Rheumatology, Statistics
Employment
  • SGPGIMS
    Additional Professor, Clinical Immunology, 2011 - present
  • SGPGIMS
    Associate Professor, Clinical Immunology, 2008 - 2011
  • SGPGIMS
    Assistant Professor, Clinical Immunology, 2004 - 2008
  • Amrita Institute of Medical Sciences
    Assistant Professor, Rheumatology and Immunology, 2004 - 2004
  • SGPGIMS
    Specialist Registrar, Clinical Immunology, 2000 - 2003
Places
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Currently
Lucknow
Previously
Kerala - Kozhikode - Chandigarh - Kochi - Thiruvananthapuram
Story
Tagline
Physician, Rheumatologist and Immunologist, Closet Geek, Mad about Birds, Photography,technology, statistics, physics, and food. Wanna be philosopher.
Introduction
Additional Professor, Department of Clinical Immunology, SGPGIMS, Lucknow
Bragging rights
Volunteered for Live vaccine Phase I trial
Collections Able is following
Education
  • SGPGIMS
    DM Clinical Immunology, 2001 - 2003
  • PGIMER
    MD Internal Medicine, 1997 - 2000
  • Kozhikode Medical College
    MBBS, 1989 - 1995
  • Sainik School Kazhakootam SSKZM
    1982 - 1989
  • St Mary's High School
    1977 - 1982
Basic Information
Gender
Male
Other names
A L Thoppil
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Able Lawrence's +1's are the things they like, agree with, or want to recommend.
Scientists find way to create supersized fruit
news.sciencemag.org

Discovery of the genetic changes that yield beefsteak tomatoes presents a new route to bigger fruits

Retardation And Religion | Shajahan Madampat | Apr 29,2015
www.outlookindia.com

The best way to kill a faith or culture is to restore it to its infancy

Visions of the Past
reflectionsonthelucknowresidency.blogspot.com

Old buildings, ruins especially, are visually difficult to deal with. Unless you are very lucky and have plans or photographs, much of the v

Guest Post: Why Everyone Hates Muslims
nicemangos.blogspot.com

Hi all, below is a guest post by fellow ex-muslim Yasmine, I love sharing your stories, perspectives and emails - if you have something you'

On Nirbhaya: No 'Honour' between my legs - Similarities between ...
nicemangos.blogspot.com

My grandparents were Indian once upon a time... Even when they were in Pakistan, post-partition, it seemed like they never really fit in. A

Why Google wants to replace Gmail | Computerworld
www.computerworld.com

Gmail represents a dying class of products that, like Google Reader, puts control in the hands of users, not signal-harvesting algorithms.

They Keep Coming Back!- Dishes!
dishesagain.blogspot.com

I absolutely dread the dishes! I would use paper plates if I could, but I know they just end up in a landfill and add extra cost to the groc

The Stay at Home Mom
stayathomemomhistory.blogspot.com

Since the dawn of time the female role has taken care of the household. Good examples are the 1950's all the way to the Amish. Back in the d

Gates Foundation to require immediate free access for journal articles
news.sciencemag.org

Policy goes further than most biomedical research funding agencies’ requirements by dispensing with embargo period

Animating
cadesjournal4.blogspot.com

About a month ago, I started learning how to animate. The animation teacher comes every alternate Saturday. When we started classes, the ins

Is the Field of Psychology Biased Against Conservatives?
www.newyorker.com

Members of the field are overwhelmingly liberal. Unsurprisingly, few see that as a problem.

Tornadoes striking United States in bunches
news.sciencemag.org

Variability in tornado occurrence rises even as average stays flat

Making Cream Cheese at home.
postmoderncuisine.blogspot.com

Making cream cheese at home We love cheese cakes, but cream cheese is not available in the super markets and when available on the rare occa

What is post modern cuisine.
postmoderncuisine.blogspot.com

Post modernism in Cuisine What is modernism? It is a phase in evolution of an art form where it critically re-evaluates its fundamentals and

Stock Photography Images Royalty Free at Can Stock Photo
www.canstockphoto.com

Affordable Royalty Free Stock Photography. Downloads for just $1.00, with thousands of images added daily. Subscriptions available for just

Ebola and "Unknown Unknowns"
blogs.hospitalmedicine.org

I did not think I would ever quote Donald Rumsfeld in one of my blog posts, but some of the missed opportunities as well as the media and pu

One Advantage of Being Endangered
www.greenhumour.com

The Amur Leopard of Russia is one of the world's most endangered animals, with only around 26 animals extant in the wild. Poaching for its f

Martian Dust Storm Is Social Media Gold Mine for India
www.latinoshealth.com

After a doubtful entry into the Martian outer orbit, India’s Mars Orbiter Mission Mangalyaan also known as the Mars Orbiter Mission, has had

Bought two items from their online store. Total fraud. Over several weeks one item still remains pending. The other was totally damaged and they dont have a return policy other than trying to force customers to accept them. They dont even email an order confirmation Their call center does not work. Here is a link to a facebook page of aggrieved customers. Buy at your peril
Public - 10 months ago
reviewed 10 months ago
Tardy delivery (Took weeks) Nasty fine print. (It says goods once accepted during delivery won't be returned or refunded). No return or refund policy for bad goods. Extremely poor packaging. Both the package and the furniture (showing outside through packaging) were damaged. Once the damaged goods were rejected, they had no policy to return it. They want to force the customer to accept the damaged goods while their terms say that they will not refund once the consignment is accepted. This is contrary to industry practice followed by other e-commerce sites like amazon or fabfurnish or shoppers stop! "This is with regards to the mail appended below. We Sincerely understand the concern. We would request you to kindly accept the consignment. The damage part would get replaced once we get to know the details. Kindly confirm back , so as to make an arrangement to deliver the material at your residence. Thanks for the assistance and patience. Warm Regards, Anand A. Asst Manager E- Commerce."
• • •
Public - 10 months ago
reviewed 10 months ago
Such a wonderful but not very famous bird sanctuary. Quite place ideal for Birding. Lots of varieties of birds. If seriously into Birding, worth several days. I went there with +Nigil Haroon
Public - a year ago
reviewed a year ago
24 reviews
Map
Map
Map
Online customer. Extremely poor delivery and post delivery service. Took weeks to deliver and then delivered damaged goods. Packaging torn and everything showing with all corners damaged. Also read fine print before buying which says, goods once accepted (at delivery time) wont be returned or refunded! Once you refuse to accept the damaged goods, they have no policy. No return policy on bad goods in this day and age unlike other main ecommerce sites like amazon or shoppers stop or fabfurnish
• • •
Public - 10 months ago
reviewed 10 months ago
Worst Movie 3D theater and the most atrocious experience ever. Glasses were so scratched and dirty, it was way better without glasses despite the double images. Avoid if you can. Saw the Sunday evening 7.50 pm show on 25th May (X Men)
Public - a year ago
reviewed a year ago