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Able Lawrence
Works at SGPGIMS
Attended SGPGIMS
Lives in Lucknow
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Able Lawrence

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Topological changes in chromosomes
Reorganisation of chromosome architecture in replicative cellular senescence, Science Advances. advances.sciencemag.org/content/2/2/e1500882

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Crystalline structure of time
The granularity of time may be manifest at intervals that are orders of magnitude larger than Planck time, with implications for quantum.
More information: Mir Faizal, et al. "Time crystals from minimum time uncertainty." The European Physical Journal C. DOI: 10.1140/epjc/s10052-016-3884-4. Also at arXiv:1501.03111 [physics.gen-ph]

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Engineered Cas9: Making genome editing enzymes more accurate
With the discovery of powerful enzyme systems like Cas9 among others that can efficiently edit DNA using a template or guiding RNA strand, genome engineering has become a reality. However unwanted mutagenesis from off target actions of the enzymes still remained. Now a group of researchers have engineered the Streptococcus pyogenes Cas9 to become more accurate without losing its efficiency for the targeted sequence offering a general strategy to improve all RNA guided endomucleases.
Genome editing: the domestication of Cas9
www.nature.com/nature/journal/v529/n7587/full/529468a.html
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
www.nature.com/nature/journal/v529/n7587/full/nature16526.html
Rationally engineered Cas9 nucleases with improved specificity
science.sciencemag.org/content/351/6268/84
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+Hyder Noori Centuries ago, transmutation of elements was the dream of alchemists. It was their dreams that led eventually to chemistry and the only thing that prevents people from making Gold by transmutation is economics. We are approaching the inflexion point in Biology. 
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From 400,000 years after the Big Bang when cosmic microwave background was formed to the time when the first stars began to shine is called Dark epoch which was dominated by neutral hydrogen which emits radio waves that get blocked by ionosphere (after being stretched by cosmic expansion. By putting a satellite behind the moon, the telescope can escape both ionosphere and our radio pollution.
A proposed spacecraft would orbit the moon, sheltering in its shadow to gaze uninterrupted into the early days of the universe.
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+Shawn H Corey​ Easier perhaps to steer and power it than from space. Also communication with it would also be easier than in some Valley on moon 
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Why do migratory songbirds sing in their wintering grounds
While songs of songbirds are usually associated with competition for mates, its got more to do with holding territory which in turn helps get suitable mates. But why do they sing in winter then? It turns practice makes better songbirds. [Image Siberian rubythroat Calliope calliope]
More information: Marjorie C. Sorensen et al. Why Do Migratory Birds Sing on Their Tropical Wintering Grounds?, The American Naturalist (2016). DOI: 10.1086/684681
Read more at: http://phys.org/news/2016-02-migratory-birds-tropical-wintering-grounds.html#jCp
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I like your beak you look so cute!!!!
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Sony today launched an entirely new brand of interchangeable lenses: the G Master. This line will represent the best of what Sony has to offer in terms of
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Gravity's rainbow
A generalisation of Einsteins relativity that attempts to solve quantum gravity removes the firewall problem.
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Nothing exists where space and time do not exist. Kids these days ...
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Legal battle at the heart of CRISPR revolution 
When is $100 million not $100 million? When it’s a proxy, maybe even something akin to a bet. The nice, round figure is the target initial public offering value for Editas Medicine, a biotechnology…
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Very interesting 
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Frankixalus jerdoni a new genus of tree frog from north east India
Citation: Biju SD, Senevirathne G, Garg S, Mahony S, Kamei RG, Thomas A, et al. (2016) Frankixalus, a New Rhacophorid Genus of Tree Hole Breeding Frogs with Oophagous Tadpoles. PLoS ONE 11(1): e0145727. doi:10.1371/journal.pone.0145727
Despite renewed interest in the biogeography and evolutionary history of Old World tree frogs (Rhacophoridae), this family still includes enigmatic frogs with ambiguous phylogenetic placement. During fieldwork in four northeastern states of India, we discovered several populations of tree hole breeding frogs with oophagous tadpoles. We used molecular data, consisting of two nuclear and three mitochondrial gene fragments for all known rhacophorid genera, to investigate the phylogenetic position of these new frogs. Our analyses identify a previously overlooked, yet distinct evolutionary lineage of frogs that warrants recognition as a new genus and is here described as Frankixalus gen. nov. This genus, which contains the enigmatic ‘Polypedates’ jerdonii described by Günther in 1876, forms the sister group of a clade containing Kurixalus, Pseudophilautus, Raorchestes, Mercurana and Beddomixalus. The distinctiveness of this evolutionary lineage is also corroborated by the external morphology of adults and tadpoles, adult osteology, breeding ecology, and life history features.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145727
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Cute lil fellow.
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Antiquity of indigenous Arabs: They descend from those who first left Africa
It was believed that while all those who came out of Africa passed through the Arabian peninsula, the current inhabitants had come back after wandering the world. New genetic study has turned that notion on its head. Rather than returning from elsewhere they represent the first cleavage of people who left Africa. This should not look surprising in retrospect. After all, Arabic and related Hebrew language is of African origin.
More information: Juan L. Rodriguez-Flores et al. Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations, Genome Research (2016).
http://dx.doi.org/10.1101/gr.191478.115
phys.org/news/2016-02-genome-human-migration-evolution.html
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Helo
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Sailing the cosmos 
Solar sails could travel to the outermost regions of the solar system faster than ever before.
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Treasure Planet?
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Enduring Mystery of the human Chin
Why do only humans have chins among the primates? 
http://onlinelibrary.wiley.com/doi/10.1002/evan.21471/abstract
The enduring puzzle of the human chin from Evolutionary Anthropology
Although modern humans are considered to be morphologically distinct from other living primates because of our large brains, dexterous hands, and bipedal gait, all of these features are found among extinct hominins. The chin, however, appears to be a uniquely modern human trait. Probably because of the chin's exclusivity, many evolutionary scenarios have been proposed to explain its origins. To date, researchers have developed adaptive hypotheses relating chins to speech, mastication, and sexual selection; still others see it as a structural artifact tangentially related to complex processes involving evolutionary retraction of the midfacial skeleton. Consensus has remained elusive, partly because hypotheses purporting to explain how this feature developed uniquely in modern humans are all fraught with theoretical and/or empirical shortcomings. Here we review a century's worth of chin hypotheses and discuss future research avenues that may provide greater insight into this human peculiarity.
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don't know really
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Able's Collections
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Work
Occupation
Doctor; Rheumatology and Clinical Immunology
Skills
Rheumatology, Immunology, Statistics, Bird Photography, Google+
Employment
  • SGPGIMS
    Additional Professor, Clinical Immunology, 2011 - present
  • SGPGIMS
    Associate Professor, Clinical Immunology, 2008 - 2011
  • SGPGIMS
    Assistant Professor, Clinical Immunology, 2004 - 2008
  • Amrita Institute of Medical Sciences
    Assistant Professor, Rheumatology and Immunology, 2004 - 2004
  • SGPGIMS
    Specialist Registrar, Clinical Immunology, 2000 - 2003
Places
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Currently
Lucknow
Previously
Kerala - Kozhikode - Chandigarh - Kochi - Thiruvananthapuram
Story
Tagline
Physician, Rheumatologist and Immunologist, Closet Geek, Mad about Birds, Photography,technology, statistics, physics, and food. Wanna be philosopher.
Introduction
Additional Professor, Department of Clinical Immunology, SGPGIMS, Lucknow
Bragging rights
Volunteered for Live vaccine Phase I trial
Education
  • SGPGIMS
    DM Clinical Immunology, 2001 - 2003
  • PGIMER
    MD Internal Medicine, 1997 - 2000
  • Kozhikode Medical College
    MBBS, 1989 - 1995
  • Sainik School Kazhakootam SSKZM
    1982 - 1989
  • St Mary's High School
    1977 - 1982
Basic Information
Gender
Male
Other names
A L Thoppil
Excellent dinner buffet with good variety. Almost everything is good with a balance of flavors, not overly spicy like other places (Just right). Dinner rates 750/head +taxes and Lunch 500/head + taxes (Lunch service only on Wednesday, Saturday and Sunday) Desserts also good. Avoid over-eating starters. Best eatery in Lucknow at this time
Public - 3 months ago
reviewed 3 months ago
A very enjoyable experience. Good Bollywood themed entertainment show which you will enjoy more if you know the filmy dialogues and songs from old Hindi films. The Culture gully was also interesting and novel, although it could have been bigger with more regions covered. The Kerala stall was a disappointment, what with the "Boat Bar" ignoring all the good things in Kerala for the Keralites penchant for the small peg.
Public - 6 months ago
reviewed 6 months ago
Within walking distance of Metro and the Business design center. Breakfast buffet was good. Wifi didnt work
Public - 7 months ago
reviewed 7 months ago
We had veal schnitzels and Pig in a blanket. Both awesome.
Public - 8 months ago
reviewed 8 months ago
30 reviews
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Tasty but very spicy. Those who like excessively spicy Indian food would love it though.
Public - 7 months ago
reviewed 7 months ago
It was worth every penny of it. For best value, book online in advance and reach on time. Leave somewhat early, even the London tube can breakdown. (It happened twice during my four days in London).
Public - 7 months ago
reviewed 7 months ago
Bought two items from their online store. Total fraud. Over several weeks one item still remains pending. The other was totally damaged and they dont have a return policy other than trying to force customers to accept them. They dont even email an order confirmation Their call center does not work. Here is a link to a facebook page of aggrieved customers. Buy at your peril
Public - a year ago
reviewed a year ago