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Asymptomatic women at high risk for MS may have early subclinical neuroimaging abnormalities
1. Women at higher risk for multiple sclerosis (MS) (based on family history, genetic testing, blood biomarkers, etc.) had significantly more early imaging and had decreased vibratory sense compared to women with lower risk of MS. 2. High-risk women did not generally have significantly decreased neurological function as compared with women at lower risk. Evidence Rating Level: 2 (Good) Study Rundown: Multiple sclerosis (MS) is an inflammatory neu...
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pH-sensitive nanoparticles reduce #cancer growth by deoxygenating tumor tissue [PreClinical]
1. Under mildly acidic in vitro conditions, silicon-based nanoparticles (NPs) effectively scavenged dissolved and hemoglobin-bound oxygen (O2) and reduced breast cancer cell viability. 2. In a mouse model of breast cancer, treatment with NPs reduced tumor tissue oxygenation and diminished tumor progression without detectable damage to vital organs. Evidence Rating Level: 2 (Good) Study Rundown: Though starving tumors of O2 and nutrie...
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Antibody-based imaging can monitor #prostatecancer progression [PreClinical]
1. In a mouse model of prostate cancer (PCa), a radiolabeled antibody (89Zr-11B6) targeting the androgen receptor (AR) pathway noninvasively detected AR-active primary and metastatic PCa lesions. 2. Using 89Zr-11B6, tumor response to treatment was monitored and demonstrated the utility of this imaging technique to assess disease activity as a function of therapeutic treatment. Evidence Rating Level: 2 (Good) Study Rundown: AR signaling activity i...
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Patient and provider interventions no better than usual care for #osteoarthritis
1. No statistically significant improvement associated with combined patient and provider intervention in osteoarthritis patients compared to usual care. 2. Physical function and depressive symptoms were similar amongst both intervention and control patient groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Osteoarthritis is a leading chronic health conditions in primary care settings. As it is a significant cause of pain and disability,...
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No difference between placebo, amitriptyline and topiramate in reducing pediatric #migraine: The CHAMP trial
1. In this study, no significant intergroup differences between amitriptyline, topiramate and placebo for reduction in total number of headache days was observed. 2. Amitriptyline and topiramate were associated with significantly higher rates of adverse side effects compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Pediatric migraine poses a substantial economic burden and reduction in quality of life for those affected. Y...
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#Tranexamicacid reduces bleeding risk during coronary artery #surgery: The ATACAS trial
1. Tranexamic acid demonstrated a significantly lower risk of bleeding complications and transfusion requirements compared to placebo in patients undergoing coronary artery surgery. 2. There was no significant increase in the risk of death or thrombotic complications associated with the use of tranexamic acid, but there was a significantly higher risk of postoperative seizure. Evidence Rating Level: 1 (Excellent) Study Rundown: There are a numbe...
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Effectiveness of meningococcal conjugate vaccine wanes after 3-8 years
1. The overall effectiveness of the meningococcal conjugate vaccine between 0 and 8 years post-vaccination was 69%. 2. The vaccine effectiveness (VE) was 79% at <1 year from vaccination, 69% at 1 to 3 years from vaccination, and 61% at 3 to 8 years from vaccination. Evidence Rating Level: 3 (Fair) Study Rundown: Being that the incidence of meningitis in the pediatric population has decreased significantly with the advent of the meningococcal conj...
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2 Minute Medicine Rewind January 16, 2017
Trial of amitriptyline, topiramate, and placebo for pediatric migraine The management of migraine headaches in the pediatric population has always been a challenge, given the lack of rigorous evidence for specific therapies. This was a multicenter, phase 3, randomized control trial held over 24 weeks that aimed to study two commonly used medications for migraine prevention, amitriptyline and topiramate. 361 patients aged 8 to 17 who suffered from...
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#Tonsillectomy may have short-term benefits in recurr#ent throat infection
1. This meta-analysis reviewed studies comparing tonsillectomy to watchful waiting and found an improvement in throat infections, healthcare utilization, and school absences within the first year after surgery. Longer-term outcomes were limited. 2. Strength of evidence (SOE) was moderate for short-term reduction in throat infections and low for healthcare utilization and school absences in the short term. In the longer term, SOE was low for no di...
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Review suggests use of standard rather than intensive blood pressure treatment in the elderly
1. In adults ≥60 years of age with a chronic systolic blood pressure (SBP) ≥150 mm Hg who are otherwise healthy, treatment to current BP guidelines (<150/90 mm Hg) greatly reduces mortality, stroke, and cardiac events. 2. Lower BP targets were linked to syncope, hypotension, and greater medication burden, but varying evidence suggests that SBP targets <120 mm Hg may be of benefit to high-risk patients. Evidence Rating Level: 1 (Excellent) Study R...
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Radiolabeled somatostatin analogue linked with improved survival in #neuroendocrinetumors
1. 177Lu-Dotatate, a radiolabeled somatostatin analogue, was associated with increased progression-free survival and decreased overall mortality compared to standard therapy in the treatment of metastatic neuroendocrine tumors of the midgut. 2. 177Lu-Dotatate therapy was linked with an increased risk of hematologic side effects as well as nausea and vomiting compared to standard therapy with best supportive care and long-acting octreotide. Eviden...
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“Weekend Warrior” physical activity patterns linked to lower #mortality
1. In this analysis of questionnaire data from surveillance studies in England and Scotland, the pattern of physical activity consisting of one to two sessions per week (termed “Weekend Warriors”) was associated with reduced all-cause mortality. 2. Both weekend warrior and more regularly active participants demonstrated similar reductions in cardiovascular mortality. The former had a trend towards decreased cancer mortality, while the latter had ...
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