Public
“What is research but a blind date with knowledge?” – William Henry
Thanks Me and my daughter love you too. Its been helpful.Jul 19, 2016
do u have a phone #? Have some questions and want to see if any discounts if gey medications from A to -Z and several orders, etc.. questionsJul 19, 2016
You seem to have lost my DNA results. My analysis was done before the FEDS inserted themselves into our business. What now? Thanks.33w
Check out this great article I read on WIRED:
A WIRED Classic about Segey Brin's new approach to solving an old problem: collect data, then hypothesize, then find patterns that lead to answers.
https://www.wired.com/2010/06/ff_sergeys_search/?mbid=email_onsiteshare
Happy's formula for parkinson's includs Vitemin E oil, Nutmeg Oil and Bamboo Carbon...
See why below...
There are relatively few causes of hormone overproduction...
overproduction (hyperfunction) or underproduction ( hypofunction) of some hormone.
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Neuron Protector and Tumor Suppressor.
In the 1980s researchers began reporting that Parkinson's patients had an overall decreased incidence of cancer, with some important exceptions, mainly melanoma.
https://academic.oup.com/jnci/article/102/6/371/952756/Parkinson-s-Disease-and-Cancer-The-Unexplored
Melanomas often resemble moles; some develop from moles. ... While it is not the most common of the skin cancers, it causes the most deaths.
CONNECTIONS?, overproduction (cancer) and underproduction (parkinson's)
"Parkinson's Disease and Cancer: The Unexplored Connection"
Mr Happy cured my sciatica in 3 weeks with "megadoses of vitamin E".
After 3 years of increasing stiffness and back pain that started in my lower back and continued down to the back of my knee as nerv pain. I researched everything about sciatica but the few options were surgical and some had BAD results.
So after I had already excepted the fact that I would be living with a sciatica problem
and be in pain for the rest of my life. I was saved....
A STUDENT FROM SAINT GEORGES UNIVERSITY HAD A EXPLANATION
OF THE CAUSE AND A POSSIBLE CURE WITCH HAS YET TO BE PUT INTO PRATICE
(BECAUSE HE WAS A NEW STUDENT AND THIS WAS NOT ALLOWED).
This Guy (I call him Happy) is amazing but the School's system is holding him back.
(He should be teaching them, Not the other way around) Did Einstien need a degree
in something only he understood, And 100 years later we still don't ?.
My back problem was not atherosclerosis as bad as to lead to Parkinson's
But Mr Happy could see the logic in it (And lot's more than that).
Happy see's more than what's in the books, but Medical school's have stupid rules...
Happy explains thing's to me in a way that even I understand. And I'm just a Sailor
The wikipedia artical below explains what he saw a little better...
"In 1945, Drs. Evan V. Shute and Wilfred E. Shute, siblings from Ontario, Canada, published the first monograph arguing that megadoses of vitamin E can slow down and even reverse the development of atherosclerosis".
The first use for vitamin E as a therapeutic agent was conducted in 1938 by Widenbauer, who used wheat germ oil supplement on 17 premature newborn infants suffering from growth failure. Eleven of the original 17 patients recovered and were able to resume normal growth rates.
https://en.wikipedia.org/wiki/Vitamin_E
Parkinson's Syndrome Sufferers may present with various combinations of back, buttock and leg pain, numbness and muscle weakness.
Parkinson’s Syndrome is a condition where the important nuclei below the brain become dysfunctional resulting in impaired communication and transmission of nerve impulses to and from nerve fibres throughout the body.
The gait deteriorates as seem as a shuffling pattern with small steps with a quickening of gait as power is mustered and spasm is overcome, Whilst there is a downhill trend the process of deterioration may arrest for periods.
Seldom does this process directly generate nerve pain such as sciatica. Back or Neck pain and pain referred in to the arm (Brachialgia) or leg (Sciatica) may arise in Parkinson’s Syndrome Sufferers as part of the Degenerative Disc Disease seen in the rest of the population and with the same pathologies
http://www.spinal-foundation.org/conditions/parkinsons-disease-sufferers
"Please help Happy WITH FUNDING or something TO CONFIRM HIS FINDINGS"...
And take his research skills where it's needed.
In my eyes, He is a pioneer waiting to be disscovered and it's sad that so far I one of few who understand's his work and knows what he can do....
Vitamin E has been linked to lower risk of PD
Vitamin E can combat the damage caused by so called "free radicals", and high dietary intake of vitamin E has been linked to lower risk of PD. Unfortunately, optimism over its use in PD has not been confirmed.---
SOME KNOWN FACTS.
Parkinson's Disease and Cancer: The Unexplored Connection
https://academic.oup.com/jnci/article/102/6/371/952756/Parkinson-s-Disease-and-Cancer-The-Unexplored---
Hormones found to affect gene activity
https://phys.org/news/2009-08-hormones-affect-gene.html---
The release of hormones by the body's glands can occur in an episodic, or ultradian, pattern, which consists of repeated periods of release that take place throughout a 24-hour, or circadian, period. Glucocorticoid hormones, which were investigated in this study, are steroid hormones secreted by the adrenal glands that are involved in a large variety of animal and human physiological responses.
"Studies of the glucocorticoid receptor typically assess gene responses after long-term stimulation with synthetic hormones. However, such treatments may not fully replicate the actual situation in living animals."
In this new study, the researchers demonstrate that ultradian hormone stimulation induces the pulsed expression of genes (known as gene pulsing) over the same period, both in cultured cells and in animal models.
The researchers conclude that, considering the wide therapeutic use of glucocorticoids for arthritis and even some cancer indications, further studies to replicate their results and follow-up studies in humans are clearly needed. Such studies will help to define the potential role of ultradian application of glucocorticoid receptor therapy.
Read more at: https://phys.org/news/2009-08-hormones-affect-gene.html#jCp---
ultradian hormone stimulation
Vitamins A and E are the most light-sensitive vitamins. Vitamin A is degraded by photolysis, while vitamin E degrades by photo-oxidation. The composition of the parenteral nutrition mixture and the container could therefore influence degradation during daylight administration.
https://www.ncbi.nlm.nih.gov/pubmed/11031072
Examples of free-running rhythms of sleep-wake and food-intake behavior by various authors are strong indicators of the endogenous nature of the circadian rhythms in infants and show that the internal clock is already functioning at birth. It is still uncertain when the process of synchronization to external and social time cues begins and how differences in the maturation of perceptive organs affect the importance of time cues for the entrainment.
https://www.ncbi.nlm.nih.gov/pubmed/10219486
Vitamins A and E are the most light-sensitive vitamins.
"Vitamin A also functions in a very different role as retinoic acid (an irreversibly oxidized form of retinol), which is an important hormone-like growth factor for epithelial and other cells".
https://en.wikipedia.org/wiki/Vitamin_A---
INTRO...
All endocrine disease stems from either an overproduction (hyperfunction) or underproduction ( hypofunction) of some hormone-secreting endocrine gland. There are relatively few causes of hormone overproduction. In general, overproduction results from hyperplasia, an increase in the number of cells (in this case, hormone-secreting cells) in a specific endocrine gland.---
Parkinson's Disease and The Endocrine System.
The Endocrine System is made up of various glands, which leads to what the system's job is. The main function is to release hormones to the body.
Parkinson's Disease is considered as one of the diseases that interrupt with the Endocrine System, it is known as an Endocrine Disrupter. Once you get this disease you will go through a lot of different kinds of stress, and especially emotional stress. This will definitely relate to the hormonal glands. To help the person feel better, there is medication available, this will also prevent drastic mood swings that they will go through.
http://aboutparkinsonsdisease.weebly.com/endocrine-system.html-
The principal molecular mechanisms that control the process and sequence of myelinogenesis are not entirely known. Numerous studies have primarily focused on simplifying the underlying neuronal control of myelinogenesis and such studies have provided several possibilities.
Although the mechanisms and processes of myelination are yet to be fully understood, some specific stages in this process have become clear:
Stage 1: Axon contact
Stage 2: Glial cell gene production
Stage 3: Axon ensheathment, which is one of two phases in the early stages of the formation of myelin sheath. Spiral ensheathment of target axons begins through the elaboration from each initiator process of lamellar extensions which extend circumferentially around the target axon and thereby form the first turn of its myelin sheath.[4]
Stage 4: Maturation
One early study focused on the signaling of oligodendrocyte myelination by regenerating peripheral axons. Researchers studied regenerating PNS axons for 28 weeks in order to investigate whether or not peripheral axons stimulate oligodendrocytes to begin myelination.
Oligodendrocytes are responsible for the creation of myelin sheaths in the central nervous system, whilst Schwann Cells are responsible in the peripheral nervous system. There are “two stages of OL markers, differentiation of OPCs to OLs, and ensheathment of axons…”
The myelination process allows neuronal signals to propagate down an axon more swiftly without the loss of signal. This enables better connectivity within specific brain regions and also improves broader neuronal pathways connecting spatially separate regions required for many sensory, cognitive, and motor functions.
On a cellular level, the study experimentally demonstrated that OLIG1 is necessary in order to stimulate myelination by oligodendrocytes in the brain. However, spinal cord related oligodendrocytes demonstrated a significantly smaller need of OLIG1 regulation in order to begin myelination.
Recent research in rats has suggested that the separate action of apotransferrin and thyroid hormone could have an important role in myelination. Moreover, research also seems to indicate that the function of transferrin and thyroid hormone together act to control myelinogenesis.
Primarily, this research indicated that due to hyperthyroidism that resulted from an increase in transferrin expression, as well as apotransferrin-dependent regulation of thyroid hormone receptor alpha, meant that transferrin was likely related to thyroid hormone’s effects on oligodendrocyte maturation, and eventually myelination.
The relationship is believed to take place at the thyroid hormone receptor level. Immunohistochemistry analysis was utilized in order to further confirm the relationship between thyroid hormone and apotransferrin during oligodendrogenesis.
The thyroid hormones act on nearly every cell in the body. They act to increase the basal metabolic rate, affect protein synthesis ?(synthesis vs production ?) , help regulate long bone growth (synergy with growth hormone) and neural maturation, and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness.
The thyroid hormones are essential to proper development and differentiation of all cells of the human body.
These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
They ? also stimulate vitamin metabolism. ??? (Thyroid hormone or thyronamines ?).
"However, the thyronamines function via some unknown mechanism to inhibit neuronal activity. One effect of administering the thyronamines is a severe drop in body temperature."
(Thyroid hormone vs thyronamines )
Numerous physiological and pathological stimuli influence thyroid hormone synthesis. Thyroid hormone leads to heat generation in humans.
pathological and stimuli
A physiological disease is a disease in which the organs or the systems in the body malfunction causing illnesses. Some examples are asthma, hypertension...
ORGANIC vs SYNTHESIZED...= BAD
"Food or beverage composition fortified with thyronamines and/or thyronamine precursors"
trace amines = BAD
Dopamine, noradrenaline, and serotonin, the trace amines have been implicated in a vast array of human disorders of affect and cognition, such as ADHD, depression and schizophrenia, among others.
Trace aminergic hypo-function ??? (Trace aminergic "OR" hypo-function).
Trace aminergic hypo-function is particularly relevant to ADHD, since urinary and plasma phenethylamine concentrations are significantly lower in ADHD individuals relative to controls and the two most commonly prescribed drugs for ADHD, amphetamine and methylphenidate, increase phenethylamine biosynthesis in treatment-responsive individuals with ADHD.
Peptide hormones are synthesized in endoplasmic reticulum, transferred to the Golgi and packaged into secretory vesicles for export. They can be secreted by one of two pathways: Regulated secretion: The cell stores hormone in secretory granules and releases them in "bursts" when stimulated.
synthesis vs production
Metabolism or metabolic processes ?
Metabolism is a biochemical process that allows an organism to live, grow, reproduce, heal, and adapt to its environment.
Anabolism and catabolism are two metabolic processes, or phases. Anabolism refers to the process which builds molecules the body needs??? (NEEDS? MOLECULES?); it usually requires energy for completion.-NOTE---
Thyronamine refers both to a molecule, and to derivatives of that molecule: a family of decarboxylated and deiodinated metabolites of the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3).--END NOTE--
NUTRITION ?.
enzyme-catalyzed reactions = GOOD.
The three main purposes of metabolism are the conversion of food/fuel to energy to
run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes.
These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments.
"Catalysts lower the activation energy for reactions. The lower the activation energy for a reaction, the faster the rate. Thus enzymes speed up reactions by lowering activation energy. Many enzymes change shape when substrates bind."
MISSING LINKS LIST....
hypo-function.
in human endocrine system: Endocrine hypofunction and receptor defects
"In some cases, a decrease in hormone production, known as hypofunction, is required to maintain homeostasis". One example of hypofunction is decreased production of thyroid hormones during starvation and illness. Because the thyroid hormones control energy expenditure, there is survival value in slowing the body’s metabolism when food intake is low. Thus, there is a distinction between...
Read More
causes of endocrine diseases
The routine monitoring of blood pressure levels is an important part of assessing an individual’s health. Blood pressure provides information about the amount of blood in circulation and about heart function and thus is an important indicator of disease.
in human disease: Diseases of metabolic-endocrine origin
All endocrine disease stems from either an overproduction (hyperfunction) or underproduction ( hypofunction) of some hormone-secreting endocrine gland. There are relatively few causes of hormone overproduction. In general, overproduction results from hyperplasia, an increase in the number of cells (in this case, hormone-secreting cells) in a specific endocrine gland. It can also be caused by...
Read More
https://www.britannica.com/science/hypofunction
PHOTOTROPH
classification of bacteria
in bacteria: Nutritional requirements
...is almost always obtained by the transfer of an electron from an electron donor to an electron acceptor. There are three basic sources of energy: light, inorganic compounds, and organic compounds. Phototrophic bacteria use photosynthesis to generate cellular energy in the form of adenosine triphosphate (ATP) from light energy. Chemotrophs obtain their energy from chemicals (organic and...
Read More
evolution of protozoans
A species of dinoflagellate known as Noctiluca scintillans, commonly called sea sparkle, is a type of algae that can aggregate into an algal bloom, producing substances that are potentially toxic to marine life.
in protozoan: Evolution and paleontology
...evolved different ways of life, and their structures became modified accordingly. As phagotrophs that ingested bacteria for food, they in some cases came to establish symbiotic associations with photosynthetic species, and ultimately the endosymbionts became plastids within the cell.
Read More
https://www.britannica.com/science/phototroph---
MORE NOTES
Vitamin E therapy in Parkinson's disease.
Though the etiology is not well understood, late-onset Parkinson's disease (PD) appears to result from several key factors including exposure to unknown environmental toxicants, toxic endogenous compounds and genetic alterations. A plethora of scientific evidence suggest that these environmental and endogenous factors cause PD by producing mitochondrial (mito) oxidative stress and damage in the substantia nigra, leading to cell death.
ncbi.nlm.nih.gov - Vitamin E therapy in Parkinson's disease. - PubMed - NCBI
Happy's formula for Parkinson’s includes Vitamin E oil, Nutmeg Oil and Bamboo Carbon...
Try it .....15w
